Evidence map›Paper›PMID 24534820›Full record

ArticleScientific reports2014

Does DcR1 (TNF-related apoptosis-inducing-ligand Receptor 3) have any role in human AMD pathogenesis?

Akshay Anand, Neel K Sharma, Ramandeep Singh, Amod Gupta, Sudesh Prabhakar, Neeru Jindal, Arvind K Bhatt, Suresh K Sharma, Pawan K Gupta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Akshay Anand1] Neuroscience Researh Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India [2].
Neel K Sharma1] Neuroscience Researh Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India [2].
Ramandeep Singh1] Department of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India [2].
Amod GuptaDepartment of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Sudesh PrabhakarNeuroscience Researh Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Neeru JindalDepartment of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Arvind K BhattDepartment of Biotechnology, Himachal Pradesh University, Shimla, India.
Suresh K SharmaDepartment of Statistics, Panjab University, Chandigarh, India.
Pawan K GuptaNeuroscience Researh Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Post Graduate Institute of Medical Education and Research · INHimachal Pradesh University · INPanjab University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been postulated that there is a link between age related degenerative diseases and cancer. The TNF-related apoptosis-inducing ligand (TRAIL) has been shown to selectively kill tumor cells by binding to pro-apoptotic and anti-apoptotic receptors. Our aim was to study the levels of anti-apoptotic receptor (DcR1) in age related macular degeneration (AMD) and controls. AMD patients (115) were classified into two groups: Dry and Wet AMD. Wet AMDs were further classified into occult, predominant classic and minimal classic. 61 healthy individuals were recruited as normal controls. After normalization with total protein, DcR1 levels were analyzed by ELISA. Mann Whitney U-statistic was used for analysis of DcR1 ELISA results. We have observed DcR1 levels in serum sample which were significantly lower in AMD patients as compared to controls (p = 0.001). On the other hand, we did not find difference in DcR1 levels between wet and dry AMD. The present study defines the plausible role of DcR1 in AMD pathology signifying a new therapeutic target for AMD.

Indexed as

ApoptosisApoptosis Regulatory ProteinsCase-Control StudiesFemaleGPI-Linked ProteinsHumansMacular DegenerationMaleMiddle AgedReceptors, Tumor Necrosis Factor, Member 10cTumor Necrosis Factor Decoy ReceptorsApoptosis Regulatory ProteinsGPI-Linked ProteinsReceptors, Tumor Necrosis Factor, Member 10cTNFRSF10C protein, humanTumor Necrosis Factor Decoy Receptors

Identifiers

PMID24534820
PMCPMC3927205
OpenAlexW1989175559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.