Evidence map›Paper›PMID 24534754›Full record

ArticleOphthalmology2014

Association between baseline iris thickness and prophylactic laser peripheral iridotomy outcomes in primary angle-closure suspects.

Roland Y Lee, Toshimitsu Kasuga, Qi N Cui, Travis C Porco, Guofu Huang, Mingguang He, Shan C Lin

Open access · greenAbstract read
In one paragraph

Article in Ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 54 citations in OpenAlex.

  1. Effects of lens extraction versus laser peripheral iridotomy on anterior segment morphology in primary angle closure suspect.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
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  12. Low iris and anterior chamber volume is associated with deepening after laser peripheral iridotomy in primary angle closure suspects.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
    Article
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  17. Observational
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  19. Functional evaluation of an iridotomy in primary angle closure eyes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 3 countries.

Roland Y LeeDepartment of Ophthalmology, University of California, San Francisco, California.
Toshimitsu KasugaDepartment of Ophthalmology, University of California, San Francisco, California; Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.
Qi N CuiDepartment of Ophthalmology, University of California, San Francisco, California.
Travis C PorcoDepartment of Ophthalmology, University of California, San Francisco, California.
Guofu HuangDepartment of Ophthalmology, University of California, San Francisco, California; Department of Ophthalmology, Nanchang University, Nanchang, Jiangxi Province, China.
Mingguang HeDepartment of Ophthalmology, University of California, San Francisco, California; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yatsen University, Guangzhou, China.
Shan C LinDepartment of Ophthalmology, University of California, San Francisco, California. Electronic address: LinS@vision.ucsf.edu.
University of California, San Francisco · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAKKARAJU, APARNA · 1985 to 2024
$16.8M
NEI NIH HHS EY002162NEI NIH HHS P30 EY002162
6 · The paper itself

Abstract

objectiveTo evaluate the association between baseline measurements of iris thickness at 3 positions and change in anterior segment biometric parameters after prophylactic laser peripheral iridotomy (LPI).

designProspective clinical cohort study.

participantsFifty-two eyes of 52 nonglaucomatous subjects with anatomically narrow angles.

methodsAnterior segment optical coherence tomography (ASOCT) images captured before and after LPI were analyzed using customized software, the Zhongshan Angle Assessment Program (ZAAP) (Zhongshan Ophthalmic Centre, Guangzhou, China). Differences in preoperative and postoperative measurements for anterior segment biometric parameters were compared by paired Student t tests. Multivariate linear regression models, adjusted for age, sex, ethnicity, and preoperative pupil diameter, were used to examine the association between the baseline measurements of iris thickness at 3 positions and the change in anterior segment biometric parameters after LPI.

main outcome measuresBaseline iris thickness measured at 750 μm from the scleral spur (IT750), iris thickness measured at 2000 μm from the scleral spur (IT2000), and maximal iris thickness (ITM). Changes in iris curvature (ICURV) and trabecular-iris space area at 500 μm from the scleral spur (TISA500) and 750 μm from the scleral spur (TISA750) after LPI.

resultsThe ICURV significantly decreased, whereas TISA500 and TISA750 significantly increased after LPI (all P < 0.0001). Lower baseline IT750 was significantly associated with greater postoperative increases in TISA500 and TISA750 (both P < 0.05). Lower baseline IT2000 and ITM were significantly associated with greater postoperative decrease in ICURV (both P < 0.05).

conclusionsOur results showed that lower baseline measurements of iris thickness are associated with greater decrease in ICURV and increases in TISA500 and TISA750 after LPI. This suggests that eyes with thinner irides undergoing LPI were more likely to exhibit greater magnitude of change in terms of flattening of the iris convexity (i.e., ICURV) and widening of the anterior chamber angle (i.e., TISA500 and TISA750).

Indexed as

AgedBiometryCohort StudiesFemaleGlaucoma, Angle-ClosureGonioscopyHumansIntraocular PressureIridectomyIrisLasers, Solid-StateMaleOrgan SizeProspective StudiesTomography, Optical CoherenceTreatment Outcome

Identifiers

PMID24534754
PMCPMC4047125
OpenAlexW1975476822

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.