Evidence map›Paper›PMID 24534522›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2015

Hippocampal and amygdalar local structural differences in elderly patients with schizophrenia.

Annapaola Prestia, Enrica Cavedo, Marina Boccardi, Cristina Muscio, Andrea Adorni, Cristina Geroldi, Matteo Bonetti, Paul M Thompson, Giovanni B Frisoni

Abstract read
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In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Annapaola PrestiaLENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS San Giovanni di Dio-FBF, Brescia, Italy.
Enrica CavedoLENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS San Giovanni di Dio-FBF, Brescia, Italy; Cognition, Neuroimaging, and Brain Diseases Laboratory, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière (CRICM-UMRS 975), Université Pierre et Marie Curie-Paris 6, France.
Marina BoccardiLENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS San Giovanni di Dio-FBF, Brescia, Italy.
Cristina MuscioLENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS San Giovanni di Dio-FBF, Brescia, Italy.
Andrea AdorniPsychogeriatric Ward - IRCCS San Giovanni di Dio-FBF, Brescia, Italy.
Cristina GeroldiLENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS San Giovanni di Dio-FBF, Brescia, Italy; Psychogeriatric Ward - IRCCS San Giovanni di Dio-FBF, Brescia, Italy.
Matteo BonettiService of Neuroradiology, Istituto Clinico Citta' di Brescia, Brescia, Italy.
Paul M ThompsonLaboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA.
Giovanni B FrisoniLENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS San Giovanni di Dio-FBF, Brescia, Italy; Memory Clinic and Laboratoire de Neuroimagerie du Vieillissement (LANVIE), University Hospitals and University of Geneva, Geneva, CH. Electronic address: gfrisoni@fatebenefratelli.it.
Istituti di Ricovero e Cura a Carattere Scientifico · ITCentro San Giovanni di Dio Fatebenefratelli · ITUniversity of California, Los Angeles · US

Funding

Amyloid Imaging, VMCI, and Analysis for ADNIRC2AG036535 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI WEINER, MICHAEL W · 2009 to 2010
$23.8M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Predictors of Alheimers Disease in Mild Cognitive ImpairmentR01AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2002 to 2011
$3.7M
Growth factors, neuroinflammation, exercise, and brain integrityRF1AG041915 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2014
$2.9M
HARDI Mapping of Disease Effects on the BrainR01EB008432 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2009 to 2012
$2.6M
A Multidimensional Alzheimer's Disease Brain AtlasR01EB008281 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2007 to 2010
$1.4M
Computational Modeling of High-Field MR ImagesR01EB007813 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2007 to 2010
$1.3M
Predictors of Alzheimers Disease in Mild Cognitive ImpairmentR56AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2007 to 2007
$482k
NIA NIH HHS AG036535NIA NIH HHS R01 AG020098NIA NIH HHS R56 AG020098NIA NIH HHS RC2 AG036535NIA NIH HHS RF1 AG041915NIBIB NIH HHS EB007813NIBIB NIH HHS EB008432NIBIB NIH HHS R01 EB007813NIBIB NIH HHS R01 EB008281NIBIB NIH HHS R01EB008281NIBIB NIH HHS R01 EB008432NIBIB NIH HHS U54 EB020403
6 · The paper itself

Abstract

objectivesMorphological abnormalities have been reported for the hippocampi and amygdalae in young schizophrenia patients, but very little is known about the pattern of abnormalities in elderly schizophrenia patients. Here we investigated local structural differences in the hippocampi and amygdalae of elderly schizophrenia patients compared with healthy elderly subjects. We also related these differences to clinical symptom severity.

design20 schizophrenia patients (mean age: 67.4 ± 6.2 years; Mini-Mental State Exam: 22.8 ± 4.4) and 20 healthy elderly subjects (70.3 ± 7.5 years; 29.0 ± 1.1) underwent high resolution magnetic resonance imaging of the brain. The Radial Atrophy Mapping technique was used to reconstruct the 3D shape of the amygdala and the hippocampus. Local differences in tissue reductions were computed between groups and permutation tests were run to correct for multiple comparisons, in statistical maps thresholded at p = 0.05.

resultsSignificant tissue reduction was observed bilaterally in the amygdala and hippocampus of schizophrenia patients. The basolateral-ventral-medial amygdalar nucleus showed the greatest involvement, with over 30% local tissue reduction. The centro-medial, cortical, and lateral nuclei were also atrophic in patients. The hippocampus showed significant tissue loss in the medio-caudal and antero-lateral aspects of CA1, and in medial section of its left head (pre- and para-subiculum). In the left amygdala and hippocampus, local tissue volumes were significantly correlated with negative symptoms.

conclusionsTissue loss and altered morphology were found in elderly schizophrenia patients. Tissue loss mapped to amygdalo-hippocampal subregions known to have bidirectional and specific connections with frontal cortical and limbic structures and was related to clinical severity.

Indexed as

AgedAged, 80 and overAgingAmygdalaFemaleHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedSchizophrenia3D-shapeamygdalaEldershippocampusschizophreniavolumetric imaging

Identifiers

PMID24534522
PMCPMC4382088
OpenAlexW2073169222

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.