Evidence map›Paper›PMID 24534443›Full record

ArticleJournal of biomedical informatics2014

Secondary use of clinical data: the Vanderbilt approach.

Ioana Danciu, James D Cowan, Melissa Basford, Xiaoming Wang, Alexander Saip, Susan Osgood, Jana Shirey-Rice, Jacqueline Kirby, Paul A Harris

2 registry-linked trialsAbstract read
In one paragraph

Article in Journal of biomedical informatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 174 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03029377 nacompletednot on this mapstarted 2017, after this paper: background citation

Noradrenergic and Stress-Related Etiologies of Chronic Fatigue Syndrome

TypeinterventionalSponsorVanderbilt University Medical CenterRan2017 to 2018Enrolled55ConditionsChronic Fatigue SyndromeArmsPosture Study, Autonomic Function Tests, and a Stress Test
NCT05277116 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

The Electronic Medical Records and GEnomics (eMERGE) Network Genomic Risk Assessment

TypeinterventionalSponsorVanderbilt University Medical CenterRan2022 to 2030Enrolled26,877ConditionsGenetic DiseaseArmsGenome Informed Risk Assessment (GIRA) report
3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  10. Albuminuria Changes as a surrogate endpoint inmedRxiv : the preprint server for health sciences · 2026
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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ioana DanciuVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States; Department of Biomedical Informatics, Vanderbilt University Medical Center, 2209 Garland Ave., Nashville, TN 37232, United States. Electronic address: Ioana.danciu@vanderbilt.edu.
James D CowanVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
Melissa BasfordVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
Xiaoming WangVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
Alexander SaipVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
Susan OsgoodVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
Jana Shirey-RiceVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
Jacqueline KirbyVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
Paul A HarrisVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States; Department of Biomedical Informatics, Vanderbilt University Medical Center, 2209 Garland Ave., Nashville, TN 37232, United States.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000445
6 · The paper itself

Abstract

The last decade has seen an exponential growth in the quantity of clinical data collected nationwide, triggering an increase in opportunities to reuse the data for biomedical research. The Vanderbilt research data warehouse framework consists of identified and de-identified clinical data repositories, fee-for-service custom services, and tools built atop the data layer to assist researchers across the enterprise. Providing resources dedicated to research initiatives benefits not only the research community, but also clinicians, patients and institutional leadership. This work provides a summary of our approach in the secondary use of clinical data for research domain, including a description of key components and a list of lessons learned, designed to assist others assembling similar services and infrastructure.

Indexed as

Database Management SystemsBiomedical ResearchElectronic Health RecordsHumansMedical InformaticsBiomedical informaticsResearch data warehouseResearch enterpriseSecondary use of clinical data

Identifiers

PMID24534443
PMCPMC4133331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.