ArticleGenome biology and evolution2014
Molecular evolution of the substrate utilization strategies and putative virulence factors in mosquito-associated Spiroplasma species.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 44 citations in OpenAlex.
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- Cytoskeletal components can turn wall-less spherical bacteria into kinking helices.Nature communications · 2022Article
- Male-killing mechanisms vary betweenFrontiers in microbiology · 2022Article
- Isolation and Characterization of Mosquito-AssociatedInsects · 2021Article
- Functional genomics of a Spiroplasma associated with the carmine cochineals Dactylopius coccus and Dactylopius opuntiae.BMC genomics · 2021Article
- ExploringFrontiers in microbiology · 2020Review
- Microbiota variations inPeerJ · 2019Article
- Genome-resolved insights into a novelPeerJ · 2019Article
- Evidence for the Cytoplasmic Localization of the L-α-Glycerophosphate Oxidase in Members of the "Frontiers in microbiology · 2019Article
- Genome Reduction in the Mosquito Symbiont Asaia.Genome biology and evolution · 2019Article
- Article
- Convergent Evolution among Ruminant-Pathogenic Mycoplasma Involved Extensive Gene Content Changes.Genome biology and evolution · 2018Article
- Horizontal Gene Acquisitions Contributed to Genome Expansion in Insect-Symbiotic Spiroplasma clarkii.Genome biology and evolution · 2018Article
- Complete Genome Sequence of Spiroplasma monobiae MQ-1Genome announcements · 2018Article
- Complete Genome Sequence of Spiroplasma floricola 23-6Genome announcements · 2018Article
- Horizontal Acquisition and Transcriptional Integration of Novel Genes in Mosquito-Associated Spiroplasma.Genome biology and evolution · 2017Article
- Complete Genome Sequence ofGenome announcements · 2017Article
- Complete Genome Sequence of Spiroplasma sp. TU-14.Genome announcements · 2017Article
- Winding paths to simplicity: genome evolution in facultative insect symbionts.FEMS microbiology reviews · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparative genomics provides a powerful tool to characterize the genetic differences among species that may be linked to their phenotypic variations. In the case of mosquito-associated Spiroplasma species, such approach is useful for the investigation of their differentiations in substrate utilization strategies and putative virulence factors. Among the four species that have been assessed for pathogenicity by artificial infection experiments, Spiroplasma culicicola and S. taiwanense were found to be pathogenic, whereas S. diminutum and S. sabaudiense were not. Intriguingly, based on the species phylogeny, the association with mosquito hosts and the gain or loss of pathogenicity in these species appears to have evolved independently. Through comparison of their complete genome sequences, we identified the genes and pathways that are shared by all or specific to one of these four species. Notably, we found that a glycerol-3-phosphate oxidase gene (glpO) is present in S. culicicola and S. taiwanense but not in S. diminutum or S. sabaudiense. Because this gene is involved in the production of reactive oxygen species and has been demonstrated as a major virulence factor in Mycoplasma, this distribution pattern suggests that it may be linked to the observed differences in pathogenicity among these species as well. Moreover, through comparative analysis with other Spiroplasma, Mycoplasma, and Mesoplasma species, we found that the absence of glpO in S. diminutum and S. sabaudiense is best explained by independent losses. Finally, our phylogenetic analyses revealed possible recombination of glpO between distantly related lineages and local rearrangements of adjacent genes.
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