ArticleJournal of epidemiology and global health2014
Availability of results from clinical research: failing policy efforts.
Article in Journal of epidemiology and global health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Time to publication for results of clinical trials.The Cochrane database of systematic reviews · 2024Pooled it
- Inadequate use and regulation of interventions against publication bias decreases their effectiveness: a systematic review.Journal of clinical epidemiology · 2015Pooled it
- Transparency in positive airway pressure therapy trials: an evaluation of reporting quality.Journal of comparative effectiveness research · 2026Article
- A microfluidic bone marrow chip for the safety profiling of biologics in pre-clinical drug development.Communications biology · 2025Article
- Open science interventions to improve reproducibility and replicability of research: a scoping review.Royal Society open science · 2025Article
- Review
- Predicting Publication of Clinical Trials Using Structured and Unstructured Data: Model Development and Validation Study.Journal of medical Internet research · 2022Article
- Epithelial Ovarian Cancer and the Immune System: Biology, Interactions, Challenges and Potential Advances for Immunotherapy.Journal of clinical medicine · 2020Review
- Scientometric measures of prospectively registered clinical trials over time: A comparison of IRCT and ClinicalTrials.gov.Medical journal of the Islamic Republic of Iran · 2020Article
- Trial2rev: Combining machine learning and crowd-sourcing to create a shared space for updating systematic reviews.JAMIA open · 2019Article
- Sponsorship, conflict of interest, risk of bias, and reporting of participant's flow and baseline demographic information in studies applicable to the federal law to post the results in clinicaltrials.gov.Contemporary clinical trials communications · 2017Article
- Published and unpublished evidence in coverage decision-making for pharmaceuticals in Europe: existing approaches and way forward.Health research policy and systems · 2016Article
- Publication proportions for registered breast cancer trials: before and following the introduction of the ClinicalTrials.gov results database.Research integrity and peer review · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTrial registration has a great potential to increase research transparency and public access to research results. This study examined the availability of results either in journal publications or in the trial registry from all studies registered at ClinicalTrials.gov.
methodsAll 137,612 records from ClinicalTrials.gov in December 2012 were merged with all 19,158 PubMed records containing registration numbers in the indexing field or in the abstracts. A multivariate analysis was conducted to examine the association between the availability of the results with study and participant characteristics available in registration records.
resultsFewer than 10% of the registered studies and 15% of the registered and completed studies had published results. The highest publication rate of 22.4% was for randomized trials completed between 2005 (starting year for structured indexing in PubMed of study registration) and 2010. For 86% of overall and 78% of completed registered studies, no results were available in ClinicalTrials.gov or in journal publications. Studies funded by industry vs. other funding sources and drug studies vs. all studies of other interventions were published less often after adjustment for study type, subject characteristics, or posting of results in ClinicalTrials.gov.
conclusionExisting policy does not ensure availability of results from clinical research. International policy revisions should charge principal investigators with ensuring that the approved protocols and posted data elements are aligned and that results are available from all conducted studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.