ArticlePhysiology & behavior2014
Exploring associations between taste perception, oral anatomy and polymorphisms in the carbonic anhydrase (gustin) gene CA6.
Article in Physiology & behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- A systematic review of the biological mediators of fat taste and smell.Physiological reviews · 2023Pooled it
- The Impact of Taste Preference-Related Gene Polymorphisms on Alcohol Consumption Behavior: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review.Frontiers in genetics · 2019Pooled it
- Time Course of Salivary Protein Responses to Cranberry-Derived Polyphenol Exposure as a Function of PROP Taster Status.Nutrients · 2020Trial
- Genetic Variants Influencing Taste Perception and Food Preferences: Current Evidence.Nutrients · 2026Review
- Taste Sensor Assessment of Bitterness in Medicines: Overview and Recent Topics.Sensors (Basel, Switzerland) · 2024Review
- Gene Methylation Affects Salivary Levels of the Taste Buds' Trophic Factor, Gustin Protein.Nutrients · 2024Article
- Article
- Automated Classification of 6-n-Propylthiouracil Taster Status with Machine Learning.Nutrients · 2022Article
- Association study of taste preference: Analysis in the Lithuanian population.Food science & nutrition · 2021Article
- Addition of chocolate milk to diet corresponds to protein concentration changes in human saliva.Physiology & behavior · 2020Article
- Investigating the Relationships between Basic Tastes Sensitivities, Fattiness Sensitivity, and Food Liking in 11-Year-Old Children.Foods (Basel, Switzerland) · 2020Article
- Predominant Qualities Evoked by Quinine, Sucrose, and Capsaicin Associate With PROP Bitterness, but not TAS2R38 Genotype.Chemical senses · 2020Article
- Article
- Salivary proteome of a Neotropical primate: potential roles in host defense and oral food perception.PeerJ · 2020Article
- Comparison of salivary proteome of children with different sensitivities for bitter and sweet tastes: association with body mass index.International journal of obesity (2005) · 2019Article
- New insights into the relationship between taste perception and oral microbiota composition.Scientific reports · 2019Article
- Carbonic Anhydrase 6 Gene Variation influences Oral Microbiota Composition and Caries Risk in Swedish adolescents.Scientific reports · 2019Article
- Carbonic Anhydrases: Role in pH Control and Cancer.Metabolites · 2018Review
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recent reports suggest that polymorphisms in the carbonic anhydrase gene CA6 (also known as gustin) may explain additional variation in the bitterness of 6-n-propylthiouracil beyond that explained by variation in the bitter receptor gene TAS2R38. CA6 (gustin) has been implicated in taste bud function and salivary buffer capacity. In the present study we examined associations between polymorphisms in the CA6 gene with salt and bitter taste perception, and oral anatomy. 243 subjects (146 female) aged 18-45 rated the intensity of five concentrations of 6-n-propylthiouracil and NaCl on a generalized Labeled Magnitude Scale (gLMS) in duplicate and one concentration of potassium chloride (KCl). Using salivary DNA, we examined 12 SNPs within CA6 in relation to taste intensity and number of fungiform papillae. We observed no difference in bitter taste perception from 6-n-propylthiouracil (PROP) or from potassium chloride for any of the SNPs examined. Perceived saltiness of NaCl on the other hand was significantly associated with a number of CA6 polymorphisms, and particularly rs3737665. Nonetheless, FP density did not vary between alleles of rs3737665, nor with any of the other CA6 SNPs. Also, we fail to find any evidence that CA6 effects on taste perception are due to differences in fungiform papilla number. Additional work is needed to confirm whether variations within the CA6 gene may be responsible for differences in salt taste perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.