Trial reportThe Journal of urology2014
Intensive lifestyle intervention reduces urinary incontinence in overweight/obese men with type 2 diabetes: results from the Look AHEAD trial.
Trial report in The Journal of urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Physical activity for lower urinary tract symptoms secondary to benign prostatic obstruction.The Cochrane database of systematic reviews · 2019Pooled it
- Implications of Look AHEAD for clinical trials and clinical practice.Diabetes, obesity & metabolism · 2014Trial
- Lifestyle Profile Scale for Gravida with Urinary Incontinence: scale development and psychometric testing in Chinese Mainland.BMJ open · 2024Article
- Impact of weight loss on the risk of urinary incontinence: the role of sex and body type.World journal of urology · 2024Article
- Association between obesity and urinary incontinence in older adults from multiple nationwide longitudinal cohorts.Communications medicine · 2023Article
- Urinary incontinence and cardiovascular disease: a narrative review.International urogynecology journal · 2020Review
- Using the Bayesian credible subgroups method to identify populations benefiting from treatment: An application to the Look AHEAD trial.PloS one · 2020Article
- Urinary Incontinence and Nocturia in Older Men: Associations with Body Mass, Composition and Strength in the Health ABC Study.The Journal of urology · 2019Article
- Liquid chromatography-mass spectrometry identification of serum biomarkers for nocturia in aged men.World journal of urology · 2019Article
- Article
- Obesity: Risk factors, complications, and strategies for sustainable long-term weight management.Journal of the American Association of Nurse Practitioners · 2017Review
- Weight Loss and Improvement in Comorbidity: Differences at 5%, 10%, 15%, and Over.Current obesity reports · 2017Review
- George A. Bray, MD: Progress in Obesity-Multidisciplinary Research, Multidimensional Man.Diabetes care · 2016Article
- Urinary Incontinence Before and After Bariatric Surgery.JAMA internal medicine · 2015Observational
- Challenging obesity: Patient, provider, and expert perspectives on the roles of available and emerging nonsurgical therapies.Obesity (Silver Spring, Md.) · 2015Article
- β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes.World journal of diabetes · 2015Review
- Importance of Beta Cell Function for the Treatment of Type 2 Diabetes.Journal of clinical medicine · 2014Review
- The Look AHEAD Trial: Implications for Lifestyle Intervention in Type 2 Diabetes Mellitus.Progress in cardiovascular diseasesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 1 country.
Funding
Abstract
purposeWe determined the effect of an intensive lifestyle intervention on the prevalence, incidence and resolution of bothersome nocturia, increased daytime urinary voiding and urinary incontinence in overweight/obese men with type 2 diabetes after 1 year in the Look AHEAD trial. MATERIALS AND
methodsA subset of male Look AHEAD participants was selected for this secondary data analysis. Overall 1,910 men with an average (mean ± SD) age of 59.9 ± 6.7 years and body mass index of 35.2 ± 5.5 kg/m(2) were randomized to an intensive lifestyle intervention or diabetes support and education group. All participants self-reported information regarding incontinence, nocturia and daytime urinary voiding at entry and 1 year.
resultsAfter 1 year the intensive lifestyle intervention group lost significantly more weight than the diabetes support and education group (9.4% ± 7.0% vs 0.7% ± 4.5%, respectively; p <0.001). The odds of prevalent urinary incontinence at 1 year were reduced by 38% in the intensive lifestyle intervention group compared to the diabetes support and education group. The prevalence of urinary incontinence decreased from 11.3% to 9.0% in the intensive lifestyle intervention group and increased from 9.7% to 11.6% in the diabetes support and education group. The intensive lifestyle intervention group also had increased odds of urinary incontinence resolving (OR 1.93, 95% CI 1.04-3.59, p = 0.04 and 56.0% vs 40.7%, p = 0.03) and trend toward reduced odds of new onset, incident urinary incontinence (OR 0.66, 95% CI 0.42-1.02, p = 0.06) compared with the diabetes support and education arm. In contrast, no differences between intensive lifestyle intervention and diabetes support and education were seen at 1 year for frequency of nocturia or frequency of daytime voiding.
conclusionsIntensive lifestyle intervention should be considered for the treatment of urinary incontinence in overweight/obese men with type 2 diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.