Evidence map›Paper›PMID 24533973›Full record

ArticleThe Journal of steroid biochemistry and molecular biology2014

Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo.

Arunoday Bhan, Imran Hussain, Khairul I Ansari, Samara A M Bobzean, Linda I Perrotti, Subhrangsu S Mandal

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of steroid biochemistry and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 1 synthesis or guideline pooled it, 172 citations in OpenAlex.

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  20. Interplay between LncRNAs and microRNAs in Breast Cancer.International journal of molecular sciences · 2023
    Review

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Arunoday BhanDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, United States.
Imran HussainDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, United States.
Khairul I AnsariDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, United States.
Samara A M BobzeanDepartment of Psychology, The University of Texas at Arlington, Arlington, TX 76019, United States.
Linda I PerrottiDepartment of Psychology, The University of Texas at Arlington, Arlington, TX 76019, United States.
Subhrangsu S MandalDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, United States. Electronic address: smandal@uta.edu.
The University of Texas at Arlington · US

Funding

Endocrine Disruptors: Assessment of endocrine disruption activity, mechanism andR15ES019129 · NIEHS · UNIVERSITY OF TEXAS ARLINGTON · PI MANDAL, SUBHRANGSU S · 2010 to 2010
$445k
Redox-Active Ruthenium Complexes for Cancer TreatmentR15CA113747 · NCI · UNIVERSITY OF TEXAS ARLINGTON · PI MACDONNELL, FREDERICK M · 2006 to 2010
$436k
NCI NIH HHS 2R15CA113747-02NCI NIH HHS R15 CA113747NIEHS NIH HHS 1R15 ES019129-01NIEHS NIH HHS R15 ES019129
6 · The paper itself

Abstract

Antisense transcript, long non-coding RNA HOTAIR is a key player in gene silencing and breast cancer and is transcriptionally regulated by estradiol. Here, we have investigated if HOTAIR expression is misregulated by bisphenol-A (BPA) and diethylstilbestrol (DES). Our findings demonstrate BPA and DES induce HOTAIR expression in cultured human breast cancer cells (MCF7) as well as in vivo in the mammary glands of rat. Luciferase assay showed that HOTAIR promoter estrogen-response-elements (EREs) are induced by BPA and DES. Estrogen-receptors (ERs) and ER-coregulators such as MLL-histone methylases (MLL1 and MLL3) bind to the HOTAIR promoter EREs in the presence of BPA and DES, modify chromatin (histone methylation and acetylation) and lead to gene activation. Knockdown of ERs down-regulated the BPA and DES-induced expression of HOTAIR. In summary, our results demonstrate that BPA and DES exposure alters the epigenetic programming of the HOTAIR promoters leading to its endocrine disruption in vitro and in vivo.

Indexed as

AcetylationAnimalsBase SequenceBenzhydryl CompoundsBisphenol A CompoundsBreast NeoplasmsDiethylstilbestrolEndocrine DisruptorsEstradiolFemaleGene ExpressionGene Expression Regulation, NeoplasticHistone-Lysine N-MethyltransferaseHistonesHumansMammary Glands, AnimalBenzhydryl Compoundsbisphenol ABisphenol A CompoundsDiethylstilbestrolEndocrine DisruptorsEstradiolHistone-Lysine N-MethyltransferaseHistonesHOTAIR long untranslated RNA, humanKMT2A protein, humanMyeloid-Lymphoid Leukemia ProteinPhenolsReceptors, EstrogenRNA, Long NoncodingBisphenol ADiethylstilbestrolEndocrine disruptionEpigeneticsHOTAIRLncRNATranscriptional regulation

Identifiers

PMID24533973
PMCPMC4025971
OpenAlexW2016941670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.