ArticleExperimental dermatology2014
Glutathione-conjugated sulfanylalkanols are substrates for ABCC11 and γ-glutamyl transferase 1: a potential new pathway for the formation of odorant precursors in the apocrine sweat gland.
Article in Experimental dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Local heating increases skin gas acetone content independent of systemic metabolism.Scientific reports · 2026Article
- Human Body Malodor and Deodorants: The Present and the Future.International journal of molecular sciences · 2025Review
- Identification of a staphylococcal dipeptidase involved in the production of human body odor.The Journal of biological chemistry · 2024Article
- Interplay of human ABCC11 transporter gene variants with axillary skin microbiome functional genomics.Scientific reports · 2024Article
- Glutamine metabolism-related genes and immunotherapy in nonspecific orbital inflammation were validated using bioinformatics and machine learning.BMC genomics · 2024Article
- Human skin gas profile of individuals with the people allergic to me phenomenon.Scientific reports · 2023Article
- The dynamic balance of the skin microbiome across the lifespan.Biochemical Society transactions · 2023Review
- The molecular basis of thioalcohol production in human body odour.Scientific reports · 2020Article
- The specific biochemistry of human axilla odour formation viewed in an evolutionary context.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Article
- A missense variant of the ABCC11 gene is associated with Axillary Osmidrosis susceptibility and clinical phenotypes in the Chinese Han Population.Scientific reports · 2017Article
- Responses of Human Neonates to Highly Diluted Odorants from Sweat.Journal of chemical ecology · 2017Article
- Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant.The pharmacogenomics journal · 2016Article
- Diagnosis of Human Axillary Osmidrosis by Genotyping of the Human ABCC11 Gene: Clinical Practice and Basic Scientific Evidence.BioMed research international · 2016Review
- The Effect of Ethnicity on Human Axillary Odorant Production.Journal of chemical ecology · 2016Article
- Multidrug Resistance Proteins (MRPs) and Cancer Therapy.The AAPS journal · 2015Review
- On the nose: genetic and evolutionary aspects of smell.Investigative genetics · 2015Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that precursors of odorous components characteristic of axillary sweat are hardly detectable or undetectable in individuals carrying the 538G > A SNP in the ABCC11 transporter gene. However, it is unclear, whether ABCC11 is directly involved in the transport of these compounds. To approach this question, transport of peptide-conjugated potential precursors of 3-methyl-3-sulfanylhexanol (3M3SH), a key determinant of axillary malodour, was measured using membrane vesicles of Sf9 insect cells overexpressing human ABCC11. Whilst no ABCC11-mediated transport was detected for the dipeptide precursor Cys-Gly-3M3SH, the glutathione conjugate of 3M3SH (SG-3M3SH) was robustly taken up by ABCC11 at a transport rate of 0.47 pmol/mg/min. Collectively, these results illuminate SG-3M3SH as a putative precursor of 3M3SH, which then may undergo intra-vesicular maturation to generate Cys-Gly-3M3SH. Critically, the apocrine sweat gland was demonstrated to express γ-glutamyl transferase 1 (GGT1) protein, which is known to catalyse the deglutamylation of glutathionyl conjugates. Additionally, we provide evidence that recombinant and isolated hepatic human GGT1 is capable of transforming SG-3M3SH to Cys-Gly-3M3SH in vitro. To sum up, we demonstrate that the functionality of ABCC11 is likely to play an important role in the generation of axillary malodour. Furthermore, we identify GGT1 as a key enzyme involved in the biosynthesis of Cys-Gly-3M3SH.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.