ArticleClinical & experimental ophthalmology
Optical coherence contrast imaging using gold nanorods in living mice eyes.
Article in Clinical & experimental ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Inorganic nanomaterials as promising therapeutic agents for ocular neovascularization: Progress and perspectives.Materials today. Bio · 2025Review
- Gold Nanoparticles for Retinal Molecular Optical Imaging.International journal of molecular sciences · 2024Review
- Recent Advances in Nanomedicine for Ocular Fundus Neovascularization Disease Management.Advanced healthcare materials · 2024Review
- Quantifying particle concentrationNanoscale · 2024Article
- Advanced nanomaterials for imaging of eye diseases.ADMET & DMPK · 2024Review
- Molecular and cellular imaging of the eye.Biomedical optics express · 2024Review
- Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration.iScience · 2023Review
- Treasure on the Earth-Gold Nanoparticles and Their Biomedical Applications.Materials (Basel, Switzerland) · 2022Review
- Gold nanomaterials for optical biosensing and bioimaging.Nanoscale advances · 2021Review
- High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice.Biomedical optics express · 2021Article
- Gold nanoparticles to enhance ophthalmic imaging.Biomaterials science · 2021Review
- Chain-like gold nanoparticle clusters for multimodal photoacoustic microscopy and optical coherence tomography enhanced molecular imaging.Nature communications · 2021Article
- Plasmonic Nanoparticles: Advanced Researches (II).Advances in experimental medicine and biology · 2021Article
- Optical Coherence Tomography Findings in the Retinas of SOD1 Knockout Mice.Translational vision science & technology · 2020Article
- Dynamic Contrast Optical Coherence Tomography reveals laminar microvascular hemodynamics in the mouse neocortex in vivo.NeuroImage · 2019Article
- Noninvasive imaging of the tree shrew eye: Wavefront analysis and retinal imaging with correlative histology.Experimental eye research · 2019Article
- Optically Active Nanomaterials for Bioimaging and Targeted Therapy.Frontiers in bioengineering and biotechnology · 2019Review
- Determination of the two-dimensional distributions of gold nanorods by multiwavelength analytical ultracentrifugation.Nature communications · 2018Article
- In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye.Scientific reports · 2017Article
- High-resolution contrast-enhanced optical coherence tomography in mice retinae.Journal of biomedical optics · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundOptical coherence tomography (OCT) is a powerful imaging modality to visualize tissue structures, with axial image pixel resolution as high as 1.6 μm in tissue. However, OCT is intrinsically limited to providing structural information as the OCT contrast is produced by optically scattering tissues.
methodsGold nanorods (GNRs) were injected into the anterior chamber (AC) and cornea of mice eyes which could create a significant OCT signal and hence could be used as a contrast agent for in vivo OCT imaging.
resultsA dose of 30 nM of GNRs (13 nm in diameter and 45 nm in length) were injected to the AC of mice eyes and produced an OCT contrast nearly 50-fold higher than control mice injected with saline. Furthermore, the lowest detectable concentration of GNRs in living mice AC was experimentally estimated to be as low as 120 pM.
conclusionsThe high sensitivity and low toxicity of GNRs brings great promise for OCT to uniquely become a high-resolution molecular imaging modality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.