ArticleInternational journal for parasitology. Parasites and wildlife2013
Trypanosomes genetic diversity, polyparasitism and the population decline of the critically endangered Australian marsupial, the brush tailed bettong or woylie (Bettongia penicillata).
Article in International journal for parasitology. Parasites and wildlife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 93 citations in OpenAlex.
- Tick-borne piroplasms and trypanosomes incidentally detected in eastern grey kangaroos (International journal for parasitology. Parasites and wildlife · 2024Article
- Kinetoplastid Species Maintained by a Small Mammal Community in the Pantanal Biome.Pathogens (Basel, Switzerland) · 2022Article
- "Visiting old, learn new": taxonomical overview of chiropteran trypanosomes from the morphology to the genes.Parasitology research · 2022Review
- Molecular Detection ofPathogens (Basel, Switzerland) · 2021Article
- Evaluation of haemoparasite andInternational journal for parasitology. Parasites and wildlife · 2021Article
- A reference genome for the critically endangered woylie,GigaByte (Hong Kong, China) · 2021Article
- Species-level identification of trypanosomes infecting Australian wildlife by High-Resolution Melting - Real Time Quantitative Polymerase Chain Reaction (HRM-qPCR).International journal for parasitology. Parasites and wildlife · 2020Article
- Blood Parasites in Endangered Wildlife-Trypanosomes Discovered During a Survey of Haemoprotozoa from the Tasmanian Devil.Pathogens (Basel, Switzerland) · 2020Article
- Meta-transcriptomic identification of Trypanosoma spp. in native wildlife species from Australia.Parasites & vectors · 2020Article
- Altered parasite community structure in an endangered marsupial following translocation.International journal for parasitology. Parasites and wildlife · 2019Article
- Increased Trypanosoma spp. richness and prevalence of haemoparasite co-infection following translocation.Parasites & vectors · 2019Article
- Debilitating disease in a polyparasitised woylie (International journal for parasitology. Parasites and wildlife · 2018Article
- The marsupial trypanosome Trypanosoma copemani is not an obligate intracellular parasite, although it adversely affects cell health.Parasites & vectors · 2018Article
- Trypanosome co-infections increase in a declining marsupial population.International journal for parasitology. Parasites and wildlife · 2018Article
- Exotic Parasite Threats to Australia's Biosecurity-Trade, Health, and Conservation.Tropical medicine and infectious disease · 2018Review
- Next generation sequencing reveals widespread trypanosome diversity and polyparasitism in marsupials from Western Australia.International journal for parasitology. Parasites and wildlife · 2018Article
- Haematozoa of wild catfishes in northern Australia.International journal for parasitology. Parasites and wildlife · 2018Article
- Article
- Trypanosomiasis in an Australian little red flying fox (Pteropus scapulatus).Australian veterinary journal · 2017Article
- A comparative molecular and 3-dimensional structural investigation into cross-continental and novel avian Trypanosoma spp. in Australia.Parasites & vectors · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
While much is known of the impact of trypanosomes on human and livestock health, trypanosomes in wildlife, although ubiquitous, have largely been considered to be non-pathogenic. We describe the genetic diversity, tissue tropism and potential pathogenicity of trypanosomes naturally infecting Western Australian marsupials. Blood samples collected from 554 live-animals and 250 tissue samples extracted from 50 carcasses of sick-euthanized or road-killed animals, belonging to 10 species of marsupials, were screened for the presence of trypanosomes using a PCR of the 18S rDNA gene. PCR results revealed a rate of infection of 67% in blood and 60% in tissues. Inferred phylogenetic trees using 18S rDNA and glycosomal glyceraldehyde phosphate dehydrogenase (gGAPDH) sequences showed the presence of eight genotypes that clustered into three clades: a clade including Trypanosoma copemani, a new clade closely related to Trypanosoma gilletti, and a clade including Trypanosoma H25 from an Australian kangaroo. Trypanosome infections were compared in a declining and in a stable population of the endangered Australian marsupial, the brush tailed bettong or woylie (Bettongia penicillata). This marsupial showed high rates of infection with Clade A genotypes (96%) in the declining population, whereas in the stable population, Clade B genotypes were predominant (89%). Mixed infections were common in woylies from the declining but not from the stable population. Histopathological findings associated with either mixed or single infections involving Clade A genotypes, showed a strong inflammatory process and tissue degeneration predominantly in heart, oesophagus and tongue. Trypanosomes were successfully grown in culture and for the first time we demonstrate that a genotype within Clade A has the capacity to not only colonize different tissues in the host but also to invade cells in vitro. These results provide evidence for the potential role of trypanosomes in the decline of a formerly abundant marsupial that is now critically endangered.
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