Evidence map›Paper›PMID 24533292›Full record

ArticleInternational journal for parasitology. Drugs and drug resistance2013

Persistent detection of Plasmodium falciparum, P. malariae, P. ovale curtisi and P. ovale wallikeri after ACT treatment of asymptomatic Ghanaian school-children.

Bismarck Dinko, Mary C Oguike, John A Larbi, Teun Bousema, Colin J Sutherland

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal for parasitology. Drugs and drug resistance, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 4 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 4 syntheses or guidelines pooled it, 116 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Molecular Markers for Sensitive Detection ofThe American journal of tropical medicine and hygiene · 2017
    Trial
  6. Trial
  7. Trial
  8. Observational
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Longitudinal analysis of the prevalence of minormedRxiv : the preprint server for health sciences · 2025
    Article
  15. Ex Vivo Drug Susceptibility ofPathogens (Basel, Switzerland) · 2025
    Article
  16. DifferentialMicrobiology spectrum · 2025
    Article
  17. Seasonal variation and interspecies dynamics amongmedRxiv : the preprint server for health sciences · 2025
    Article
  18. Plasmodium ovale Malaria in Travelers and Immigrants to the United States: A Case Series.The American journal of tropical medicine and hygiene · 2025
    Article
  19. Review
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Bismarck DinkoDept. of Immunology & Infection, London School of Hygiene & Tropical Medicine, London, UK.
Mary C OguikeDept. of Immunology & Infection, London School of Hygiene & Tropical Medicine, London, UK.
John A LarbiDept. of Biology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Teun BousemaDept. of Immunology & Infection, London School of Hygiene & Tropical Medicine, London, UK ; Dept. of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Colin J SutherlandDept. of Immunology & Infection, London School of Hygiene & Tropical Medicine, London, UK ; Dept. of Clinical Parasitology, Hospital for Tropical Diseases, UCL Hospitals Trust, London, UK.
London School of Hygiene & Tropical Medicine · GBKwame Nkrumah University of Science and Technology · GH

Funding

Wellcome Trust
6 · The paper itself

Abstract

Two hundred and seventy four asymptomatic Ghanaian school-children aged 5 to 17 years were screened for malaria parasites by examination of blood films. One hundred and fifty five microscopically-positive individuals were treated with dihydroartemisinin-piperaquine and followed for 3 weeks. Retrospective species-specific PCR of all 274 screened samples identified an additional 60 children with sub-patent parasitaemia, and a substantial proportion of co-infections with Plasmodium malariae, Plasmodium ovale curtisi and Plasmodium ovale wallikeri. One hundred individuals harboured at least one non-falciparum parasite species. Using standard double-read microscopy, the 21-day efficacy of treatment against Plasmodium falciparum was 91.4% among the 117 children seen at all 5 visits. Using nested PCR to test 152 visit 5 blood samples, 22 were found to be parasite-positive. Twenty individuals harboured P. falciparum, four harboured P. ovale spp. and two P. malariae, with four of these 22 isolates being mixed species infections. The persistent detection of low density Plasmodium sp. infections following antimalarial treatment suggests these may be a hitherto unrecognised obstacle to malaria elimination.

Indexed as

ACTAsymptomatic malariaPlasmodium malariaePlasmodium ovale spp.

Identifiers

PMID24533292
PMCPMC3862415
OpenAlexW2131828511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.