Evidence map›Paper›PMID 24533255›Full record

ReviewTissue barriers2013

Potentiometric-scanning ion conductance microscopy for measurement at tight junctions.

Yi Zhou, Chiao-Chen Chen, Anna E Weber, Lushan Zhou, Lane A Baker, Jianghui Hou

Open access · bronzeAbstract readReview
In one paragraph

Review in Tissue barriers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Multifunctional scanning ion conductance microscopy.Proceedings. Mathematical, physical, and engineering sciences · 2017
    Review
  5. Nanopore Sensing.Analytical chemistry · 2017
    Review
  6. Claudins in barrier and transport function-the kidney.Pflugers Archiv : European journal of physiology · 2017
    Review
  7. Article
  8. The kidney tight junction (Review).International journal of molecular medicine · 2014
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yi ZhouDepartment of Chemistry; Indiana University; Bloomington, IN USA.
Chiao-Chen ChenDepartment of Chemistry; Indiana University; Bloomington, IN USA.
Anna E WeberDepartment of Chemistry; Indiana University; Bloomington, IN USA.
Lushan ZhouDepartment of Chemistry; Indiana University; Bloomington, IN USA.
Lane A BakerDepartment of Chemistry; Indiana University; Bloomington, IN USA.
Jianghui HouRenal Division; Washington University Medical School; St. Louis, MO USA ; Center for Investigation of Membrane Excitability Diseases; Washington University Medical School; St. Louis, MO USA.
Indiana University · USUniversity of Missouri–St. Louis · US

Funding

Washington University Center for Kidney Disease ResearchP30DK079333 · NIDDK · WASHINGTON UNIVERSITY · PI HAMMERMAN, MARC RANDALL · 2007 to 2011
$5.1M
BIOCHEMICAL AND BIOPHYSICAL NATURE OF CLAUDIN-16 AND CLAUDIN-19 CHANNELSR01DK084059 · NIDDK · WASHINGTON UNIVERSITY · PI HOU, JIANGHUI · 2010 to 2018
$2.9M
Electrochemical Imaging of in vitro Tight Junctions with Scanning Ion ConductanceR21DK082990 · NIDDK · TRUSTEES OF INDIANA UNIVERSITY · PI BAKER, LANE A. · 2010 to 2011
$402k
NIDDK NIH HHS P30 DK079333NIDDK NIH HHS R01 DK084059NIDDK NIH HHS R21 DK082990
6 · The paper itself

Abstract

Scanning Ion Conductance Microscopy (SICM) has been developed originally for high-resolution imaging of topographic features. Recently, we have described a hybrid voltage scanning mode of SICM, termed Potentiometric-SICM (P-SICM) for recording transmembrane ionic conductance at specific nanostructures of synthetic and biological interfaces. With this technique, paracellular conductance through tight junctions - a subcellular structure that has been difficult to interrogate previously - has been realized. P-SICM utilizes a dual-barrel pipet to differentiate paracellular from transcellular transport processes with nanoscale spatial resolution. The unique combination of voltage scanning and topographic imaging enables P-SICM to capture paracellular conductance within a nominal radius of several hundred nanometers. This review summarizes recent advances in paracellular conductance recording with an emphasis on the P-SICM based approach, which is applied to detect claudin-2 mediated permeability changes at the tight junction.

Indexed as

claudinepitheliumion channelpatch clampSICMtight junction

Identifiers

PMID24533255
PMCPMC3805658
OpenAlexW2056427469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.