Evidence map›Paper›PMID 24533234›Full record

ArticleCurrent nutrition reports2014

The association between adiposity and breast cancer recurrence and survival: A review of the recent literature.

Maria Azrad, Wendy Demark-Wahnefried

Registry-linked trialAbstract read
In one paragraph

Article in Current nutrition reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03935282 (Assessing Effectiveness and Implementation of an EHR Tool to Assess Heart Health Among Survivors), which is not on this map. Cited by 63 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 4 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03935282 nacompletednot on this mapstarted 2020, after this paper: background citation

Assessing Effectiveness and Implementation of an EHR Tool to Assess Heart Health Among Survivors (AH-HA)

TypeinterventionalSponsorWake Forest University Health SciencesRan2020 to 2025Enrolled645ConditionsBreast Neoplasm, Prostatic Neoplasm, Colorectal Neoplasms, Endometrial NeoplasmsArmsAH-HA Tool in the EPIC EHR
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 4 syntheses or guidelines pooled it, 123 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Body Mass Index at Diagnosis and Breast Cancer Survival Prognosis in Clinical Trial Populations from NRG Oncology/NSABP B-30, B-31, B-34, and B-38.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016
    Trial
  10. Trial
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Social-cognitive, demographic, clinical, and health-related correlates of physical activity and sedentary behaviour in newly diagnosed women with breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria AzradDepartment of Nutrition Sciences, University of Alabama at Birmingham (UAB), 1824 6th Avenue, 310B Wallace Tumor Institute, Birmingham, AL 35294.
Wendy Demark-WahnefriedDepartment of Nutrition Sciences, University of Alabama at Birmingham (UAB), 1824 6th Avenue, 310B Wallace Tumor Institute, Birmingham, AL 35294 ; UAB Comprehensive Cancer Center, University of Alabama at Birmingham, 1824 6th Avenue, 310D Wallace Tumor Institute, Birmingham, AL 35294.
University of Alabama at Birmingham · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8M
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Cancer Prevention & Control Training ProgramR25CA047888 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEMARK-WAHNEFRIED, WENDY, MENESES, KAREN M · 1988 to 2016
$11.2M
Reducing Breast Cancer Recurrence with Weight Loss: A Vanguard TrialR01CA148791 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROCK, CHERYL L · 2010 to 2013
$4.9M
UAB Cancer Prevention and Control Training Program (T32)T32CA047888 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Ritu Aneja, Ellen Mary Lavoie Smith · 2018 to 2026
$3.2M
NCI NIH HHS P30 CA013148NCI NIH HHS P30 CA014236NCI NIH HHS R01 CA148791NCI NIH HHS R25 CA047888NCI NIH HHS T32 CA047888
6 · The paper itself

Abstract

Breast Cancer (BC) is the most common and second deadliest malignancy among American women. Many factors contribute to BC prognosis but a key modifiable lifestyle factor is body weight. In this review, we update the reader on the association between adiposity and poor BC outcomes. We summarize the findings from studies that show obesity to be a risk factor for BC recurrence and reduced survival, including research that shows that treatment with aromatase inhibitors in hormone-receptor positive BC survivors who are obese may not be as effective as in normal weight women. In addition, we summarize the findings from studies that show that obesity-induced changes in glucose metabolism, type-2 diabetes and metabolic syndrome contribute to negative outcomes in BC survivors. Given the evidence, there is a critical need to determine whether weight loss can improve outcomes in BC survivors.

Indexed as

adiposityaromatasearomatase inhibitorbody fatbody mass indexbody weightbreast neoplasmsc-peptideestrogenestrogen-receptor positiveglucoseglucose metabolismHOMAhormone-receptor positivehormonesinsulinmetabolic syndromemortalityobesityoverweightrecurrencesurvivaltype 2 diabetes

Identifiers

PMID24533234
PMCPMC3921906
OpenAlexW2084451319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.