ArticleCartilage2013
Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity: Comparison of Agarose and Self-Assembling Peptide Scaffolds.
Article in Cartilage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Prognostic analysis of steroid-induced osteonecrosis of the femoral head in children with immune kidney disease.Annals of medicine · 2025Article
- Unlocking the potential of injectable hydrogels for cartilage repair.Regenerative medicine · 2025Review
- MiR-218-5p-dependent SOCS3 downregulation increases osteoblast differentiation inpostmenopausal osteoporosis.Journal of orthopaedic surgery and research · 2023Article
- Glucocorticoid Effects on Proteoglycans and Glycosaminoglycans.International journal of molecular sciences · 2022Review
- Culture Conditions that Support Expansion and Chondrogenesis of Middle-Aged Rat Mesenchymal Stem Cells.Cartilage · 2020Article
- Bio-instructive materials for musculoskeletal regeneration.Acta biomaterialia · 2019Review
- Bone Tissue Engineering in a Perfusion Bioreactor Using Dexamethasone-Loaded Peptide Hydrogel.Materials (Basel, Switzerland) · 2019Article
- Role of dexamethasone in the long-term functional maturation of MSC-laden hyaluronic acid hydrogels for cartilage tissue engineering.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Impact of dexamethasone concentration on cartilage tissue formation from human synovial derived stem cells in vitro.Cytotechnology · 2018Article
- Cell-laden hydrogels for osteochondral and cartilage tissue engineering.Acta biomaterialia · 2017Review
- Possible role of the Ec peptide of IGF‑1Ec in cartilage repair.Molecular medicine reports · 2016Article
- Self-assembling peptides for stem cell and tissue engineering.Biomaterials science · 2016Article
- Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α.Tissue engineering. Part A · 2016Article
- Effects of Dexamethasone Concentration and Timing of Exposure on Chondrogenesis of Equine Bone Marrow-Derived Mesenchymal Stem Cells.Cartilage · 2016Article
- Effects of corticosteroids and their combinations with hyaluronanon on the biochemical properties of porcine cartilage explants.BMC veterinary research · 2015Article
- Delivering heparin-binding insulin-like growth factor 1 with self-assembling peptide hydrogels.Tissue engineering. Part A · 2015Article
- Article
- Evaluation of culture conditions forConnective tissue researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveDexamethasone (Dex) is a synthetic glucocorticoid that has pro-anabolic and anti-catabolic effects in cartilage tissue engineering systems, though the mechanisms by which these effects are mediated are not well understood. We tested the hypothesis that the addition of Dex to chondrogenic medium would affect matrix production and aggrecanase activity of human and bovine bone marrow stromal cells (BMSCs) cultured in self-assembling peptide and agarose hydrogels.
designWe cultured young bovine and adult human BMSCs in (RADA)
resultsDex improved proteoglycan synthesis and retention in agarose hydrogels seeded with young bovine cells, but decreased proteoglycan accumulation in peptide scaffolds. These effects were mediated by the glucocorticoid receptor. Adult human BMSCs showed minimal matrix accumulation in agarose, but accumulated ~50% as much proteoglycan and collagen as young bovine BMSCs in peptide hydrogels. Dex reduced aggrecanase activity in (RADA)
conclusionsThe effects of Dex on matrix production are dependent on cell source and hydrogel identity. This is the first report of Dex reducing aggrecanase activity in a tissue engineering culture system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.