ArticlePloS one2014
High-throughput sequence typing reveals genetic differentiation and host specialization among populations of the Borrelia burgdorferi species complex that infect rodents.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Distribution and Genetic Diversity ofPathogens (Basel, Switzerland) · 2026Article
- From reservoirs to ecological integrators: the role of EuropeanFrontiers in veterinary science · 2026Review
- Genetic landscape of Borrelia burgdorferi sensu stricto in Canada: a study of genetic diversity.Scientific reports · 2025Article
- Prevalence of Lyme Disease and Relapsing FeverPathogens (Basel, Switzerland) · 2024Review
- Using mechanistic models to highlight research priorities for tick-borne zoonotic diseases: Improving our understanding of the ecology and maintenance of Kyasanur Forest Disease in India.PLoS neglected tropical diseases · 2023Article
- Maternal Antibodies Provide Bank Voles with Strain-Specific Protection against Infection by the Lyme Disease Pathogen.Applied and environmental microbiology · 2019Article
- Susceptibility to infection with Borrelia afzelii and TLR2 polymorphism in a wild reservoir host.Scientific reports · 2019Article
- The genetic diversity of Borrelia afzelii is not maintained by the diversity of the rodent hosts.Parasites & vectors · 2018Article
- Fitness estimates from experimental infections predict the long-term strain structure of a vector-borne pathogen in the field.Scientific reports · 2017Article
- Molecular characterization of 'Candidatus Borrelia tachyglossi' (family Spirochaetaceae) in echidna ticks, Bothriocroton concolor.International journal of systematic and evolutionary microbiology · 2017Article
- The enzootic life-cycle of Borrelia burgdorferi (sensu lato) and tick-borne rickettsiae: an epidemiological study on wild-living small mammals and their ticks from Saxony, Germany.Parasites & vectors · 2017Article
- Multistrain Infections with Lyme Borreliosis Pathogens in the Tick Vector.Applied and environmental microbiology · 2017Article
- Infection of Ixodes ricinus by Borrelia burgdorferi sensu lato in peri-urban forests of France.PloS one · 2017Article
- Comparison of the lifetime host-to-tick transmission between two strains of the Lyme disease pathogen Borrelia afzelii.Parasites & vectors · 2016Article
- Multiple independent transmission cycles of a tick-borne pathogen within a local host community.Scientific reports · 2016Article
- TRANSLATING ECOLOGY, PHYSIOLOGY, BIOCHEMISTRY, AND POPULATION GENETICS RESEARCH TO MEET THE CHALLENGE OF TICK AND TICK-BORNE DISEASES IN NORTH AMERICA.Archives of insect biochemistry and physiology · 2016Review
- Article
- Multi-trophic interactions driving the transmission cycle of Borrelia afzelii between Ixodes ricinus and rodents: a review.Parasites & vectors · 2015Review
- Cross-Immunity and Community Structure of a Multiple-Strain Pathogen in the Tick Vector.Applied and environmental microbiology · 2015Article
- An Invasive Mammal (the Gray Squirrel, Sciurus carolinensis) Commonly Hosts Diverse and Atypical Genotypes of the Zoonotic Pathogen Borrelia burgdorferi Sensu Lato.Applied and environmental microbiology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lyme disease is a zoonosis caused by various species belonging to the Borrelia burgdorferi bacterial species complex. These pathogens are transmitted by ticks and infect multiple, taxonomically distinct, host species. From an epidemiological perspective, it is important to determine whether genetic variants within the species complex are able to spread freely through the whole host community or, instead, if certain variants are restricted to particular hosts. To this end, we characterized the genotypes of members of the B. burgdorferi species complex; the bacteria were isolated from more than two hundred individuals captured in the wild and belonging to three different rodent host species. For each individual, we used a high-throughput approach to amplify and sequence rplB, a housekeeping gene, and ospC, which is involved in infection. This approach allowed us to evaluate the genetic diversity both within and among species in the B. burgdorferi species complex. Strong evidence of genetic differentiation among host species was revealed by both genes, even though they are, a priori, not constrained by the same selective pressures. These data are discussed in the context of the advancements made possible by multi-locus high-throughput sequencing and current knowledge of Lyme disease epidemiology.
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