ArticlePloS one2014
Extensive expression differences along porcine small intestine evidenced by transcriptome sequencing.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
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- Kynurenine promotes porcine intestinal epithelial cell proliferation by activating the AHR-MST1-YAP1 axis.Journal of animal science and biotechnology · 2026Article
- Transcriptomic profiling of porcine duodenal, jejunal, and ileal organoids in response to porcine epidemic diarrhea virus.Journal of animal science and technology · 2026Article
- Mining chicken ileal microbiota for immunomodulatory microorganisms.The ISME journal · 2023Article
- Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells.Life science alliance · 2022Article
- Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs.Frontiers in genetics · 2022Article
- Drivers of transcriptional variance in human intestinal epithelial organoids.Physiological genomics · 2021Article
- Pig genome functional annotation enhances the biological interpretation of complex traits and human disease.Nature communications · 2021Article
- Single-cell multi-omics analysis presents the landscape of peripheral blood T-cell subsets in human chronic prostatitis/chronic pelvic pain syndrome.Journal of cellular and molecular medicine · 2020Article
- Transcriptomics in Toxicogenomics, Part III: Data Modelling for Risk Assessment.Nanomaterials (Basel, Switzerland) · 2020Review
- Article
- Phytogenic actives supplemented in hyperprolific sows: effects on maternal transfer of phytogenic compounds, colostrum and milk features, performance and antioxidant status of sows and their offspring, and piglet intestinal gene expression.Journal of animal science · 2020Article
- Gene expression profiles of the small intestine of village chickens from anVeterinary parasitology: X · 2019Article
- Small intestinal transcriptome analysis revealed changes of genes involved in nutrition metabolism and immune responses in growth retardation piglets1.Journal of animal science · 2019Article
- Exploring Differential Transcriptome between Jejunal and Cecal Tissue of Broiler Chickens.Animals : an open access journal from MDPI · 2019Article
- A RNA-Seq Analysis to Describe the Boar Sperm Transcriptome and Its Seasonal Changes.Frontiers in genetics · 2019Article
- Immunome differences between porcine ileal and jejunal Peyer's patches revealed by global transcriptome sequencing of gut-associated lymphoid tissues.Scientific reports · 2018Article
- Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis.BMC genomics · 2017Article
- Gene expression profile changes in the jejunum of weaned piglets after oral administration of Lactobacillus or an antibiotic.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to analyse gene expression along the small intestine (duodenum, jejunum, ileum) and in the ileal Peyer's patches in four young pigs with no clinical signs of disease by transcriptome sequencing. Multidimensional scaling evidenced that samples clustered by tissue type rather than by individual, thus prefiguring a relevant scenario to draw tissue-specific gene expression profiles. Accordingly, 1,349 genes were found differentially expressed between duodenum and jejunum, and up to 3,455 genes between duodenum and ileum. Additionally, a considerable number of differentially expressed genes were found by comparing duodenum (7,027 genes), jejunum (6,122 genes), and ileum (6,991 genes) with ileal Peyer's patches tissue. Functional analyses revealed that most of the significant differentially expressed genes along small intestinal tissues were involved in the regulation of general biological processes such as cell development, signalling, growth and proliferation, death and survival or cell function and maintenance. These results suggest that the intrinsic large turnover of intestinal tissues would have local specificities at duodenum, ileum and jejunum. In addition, in concordance with their biological function, enteric innate immune pathways were overrepresented in ileal Peyer's patches. The reported data provide an expression map of the cell pathway variation in the different small intestinal tissues. Furthermore, expression levels measured in healthy individuals could help to understand changes in gene expression that occur in dysbiosis or pathological states.
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