ArticlePloS one2014
Candidate gene approach for parasite resistance in sheep--variation in immune pathway genes and association with fecal egg count.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Exploration and Enrichment Analysis of the QTLome for Important Traits in Livestock Species.Genes · 2024Article
- Characterization of interferon gamma gene in relation to immunological responses in Haemonchus contortus resistant and susceptible Garole sheep.Veterinary research communications · 2023Article
- Article
- Genome-Wide Association Study of Parasite Resistance to Gastrointestinal Nematodes in Corriedale Sheep.Genes · 2022Article
- New Insight into the Genome-Wide Diversity and Admixture of Six Colombian Sheep Populations.Genes · 2022Article
- Vaccine-induced time- and age-dependent mucosal immunity to gastrointestinal parasite infection.NPJ vaccines · 2022Article
- A Review of the Impact of Climate Change on the Epidemiology of Gastrointestinal Nematode Infections in Small Ruminants and Wildlife in Tropical Conditions.Pathogens (Basel, Switzerland) · 2022Review
- Trickle infection withFrontiers in immunology · 2022Article
- Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits.Frontiers in genetics · 2021Article
- Genome-wide association study to identify genetic loci associated with gastrointestinal nematode resistance in Katahdin sheep.Animal genetics · 2020Article
- Article
- Association study reveals Th17, Treg, and Th2 loci related to resistance to Haemonchus contortus in Florida Native sheep1.Journal of animal science · 2019Article
- Single nucleotide polymorphisms in candidate genes are significantly associated with resistance toJournal of animal science and biotechnology · 2019Article
- Single-nucleotide polymorphism-based genetic diversity analysis of the Kilakarsal and Vembur sheep breeds.Veterinary world · 2017Article
- Comparison of the in vitro anthelmintic effects of Acacia nilotica and Acacia raddiana.Parasite (Paris, France) · 2017Article
- Breeding for resistance to gastrointestinal nematodes - the potential in low-input/output small ruminant production systems.Veterinary parasitology · 2016Review
- Possible mechanisms of host resistance to Haemonchus contortus infection in sheep breeds native to the Canary Islands.Scientific reports · 2016Article
- Genomic prediction and genome-wide association study for dagginess and host internal parasite resistance in New Zealand sheep.BMC genomics · 2015Article
- Relative resistance of Menz and Washera sheep breeds to artificial infection with Haemonchus contortus in the highlands of Ethiopia.Tropical animal health and production · 2015Article
- Recent advances in understanding the genetic resources of sheep breeds locally-adapted to the UK uplands: opportunities they offer for sustainable productivity.Frontiers in genetics · 2015Review
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sheep chromosome 3 (Oar3) has the largest number of QTLs reported to be significantly associated with resistance to gastro-intestinal nematodes. This study aimed to identify single nucleotide polymorphisms (SNPs) within candidate genes located in sheep chromosome 3 as well as genes involved in major immune pathways. A total of 41 SNPs were identified across 38 candidate genes in a panel of unrelated sheep and genotyped in 713 animals belonging to 22 breeds across Asia, Europe and South America. The variations and evolution of immune pathway genes were assessed in sheep populations across these macro-environmental regions that significantly differ in the diversity and load of pathogens. The mean minor allele frequency (MAF) did not vary between Asian and European sheep reflecting the absence of ascertainment bias. Phylogenetic analysis revealed two major clusters with most of South Asian, South East Asian and South West Asian breeds clustering together while European and South American sheep breeds clustered together distinctly. Analysis of molecular variance revealed strong phylogeographic structure at loci located in immune pathway genes, unlike microsatellite and genome wide SNP markers. To understand the influence of natural selection processes, SNP loci located in chromosome 3 were utilized to reconstruct haplotypes, the diversity of which showed significant deviations from selective neutrality. Reduced Median network of reconstructed haplotypes showed balancing selection in force at these loci. Preliminary association of SNP genotypes with phenotypes recorded 42 days post challenge revealed significant differences (P<0.05) in fecal egg count, body weight change and packed cell volume at two, four and six SNP loci respectively. In conclusion, the present study reports strong phylogeographic structure and balancing selection operating at SNP loci located within immune pathway genes. Further, SNP loci identified in the study were found to have potential for future large scale association studies in naturally exposed sheep populations.
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