ArticlePloS one2014
Saliva microbiota carry caries-specific functional gene signatures.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- The Role of Oxidative Stress-Related Gene Polymorphisms (Medicina (Kaunas, Lithuania) · 2025Article
- Salivary microbiome and metabolome analysis of severe early childhood caries.BMC oral health · 2023Article
- Microbiome and metabolome associated with white spot lesions in patients treated with clear aligners.Frontiers in cellular and infection microbiology · 2023Article
- Article
- Fecal Microbiota Functional Gene Effects Related to Single-Dose Antibiotic Treatment of Travelers' Diarrhea.Open forum infectious diseases · 2021Article
- Oral Microbiome Alterations Associated with Early Childhood Caries Highlight the Importance of Carbohydrate Metabolic Activities.mSystems · 2019Article
- From an imbalance to a new imbalance: Italian-style gluten-free diet alters the salivary microbiota and metabolome of African celiac children.Scientific reports · 2015Article
- [Oral microbiota: a promising predictor of human oral and systemic diseases].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2015Article
- Progress in oral personalized medicine: contribution of 'omics'.Journal of oral microbiology · 2015Article
- Functional expression of dental plaque microbiota.Frontiers in cellular and infection microbiology · 2014Article
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Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human saliva microbiota is phylogenetically divergent among host individuals yet their roles in health and disease are poorly appreciated. We employed a microbial functional gene microarray, HuMiChip 1.0, to reconstruct the global functional profiles of human saliva microbiota from ten healthy and ten caries-active adults. Saliva microbiota in the pilot population featured a vast diversity of functional genes. No significant distinction in gene number or diversity indices was observed between healthy and caries-active microbiota. However, co-presence network analysis of functional genes revealed that caries-active microbiota was more divergent in non-core genes than healthy microbiota, despite both groups exhibited a similar degree of conservation at their respective core genes. Furthermore, functional gene structure of saliva microbiota could potentially distinguish caries-active patients from healthy hosts. Microbial functions such as Diaminopimelate epimerase, Prephenate dehydrogenase, Pyruvate-formate lyase and N-acetylmuramoyl-L-alanine amidase were significantly linked to caries. Therefore, saliva microbiota carried disease-associated functional signatures, which could be potentially exploited for caries diagnosis.
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