ArticleSoft matter2013
Gradient-free directional cell migration in continuous microchannels.
Article in Soft matter, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- 3D-printed plugs enhance cell usage efficiency for single-cell migration and neuron axon guidance assays.Cell reports methods · 2025Article
- Shape of scaffold controlling the direction of cell migration.Biophysics and physicobiology · 2024Article
- Microfluidic single-cell migration chip reveals insights into the impact of extracellular matrices on cell movement.Lab on a chip · 2023Article
- High-Throughput Cellular Heterogeneity Analysis in Cell Migration at the Single-Cell Level.Small (Weinheim an der Bergstrasse, Germany) · 2023Article
- Effect of Kelulut Honey on the Cellular Dynamics of TGFβ-Induced Epithelial to Mesenchymal Transition in Primary Human Keratinocytes.International journal of environmental research and public health · 2020Article
- An integrated method for cell isolation and migration on a chip.Scientific reports · 2017Article
- Engineering Dynamic Biointerfaces.Current opinion in chemical engineering · 2016Article
- Effective Spatial Separation of PC12 and NIH3T3 Cells by the Microgrooved Surface of Biocompatible Polymer Substrates.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Single-cell Migration Chip for Chemotaxis-based Microfluidic Selection of Heterogeneous Cell Populations.Scientific reports · 2015Article
- Cells as active particles in asymmetric potentials: motility under external gradients.Biophysical journal · 2014Article
- Microfabricated Systems and Assays for Studying the Cytoskeletal Organization, Micromechanics, and Motility Patterns of Cancerous Cells.Advanced materials interfaces · 2014Article
- Protrusion fluctuations direct cell motion.Biophysical journal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Directing cell movements within 3D channels is a key challenge in biomedical devices and tissue engineering. In two dimensions, closely spaced arrays of asymmetric teardrop islands can intermittently polarize cells and sustain their autonomous directional migration with no gradients. However, in 3D microchannels composed of linearly connected teardrop segments, negligibly low directional bias is observed. Rather than adopt teardrop shapes, cells evade morphological polarization by spreading across multiple teardrop segments, only partly filling each. We demonstrate here that cells can be forced to adopt the shape of individual segments by connecting the segments at an angle to minimize cell spreading across multiple segments. The resulting rhythmic polarization leads to significant directional bias for NIH3T3 fibroblasts, epithelial cells, and even cells whose intracellular signalling have been purposely altered to affect lamellipodia extension (Rac1) and cell polarity (Cdc42). This gradient-free approach to directing cell migration in 3D microchannels may find significant applications in tissue scaffolds and cell on a chip devices.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.