ArticleThe Journal of infectious diseases2014
Heterogeneity of CD4+ and CD8+ T-cell responses to cytomegalovirus in HIV-infected and HIV-uninfected men who have sex with men.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Breadth and polyfunctionality of T cell responses to human cytomegalovirus in men who have sex with men: relationship with HIV infection and frailty.Journal of virology · 2024Article
- Longitudinal association of cytokine-producing CMV-specific T cells with frailty in HIV-infected and -uninfected men who have sex with men.Immunity & ageing : I & A · 2022Article
- Cytomegalovirus as an Uninvited Guest in the Response to Vaccines in People Living with HIV.Viruses · 2021Review
- Antigen-driven clonal selection shapes the persistence of HIV-1-infected CD4+ T cells in vivo.The Journal of clinical investigation · 2021Article
- Aging, sex, inflammation, frailty, and CMV and HIV infections.Cellular immunology · 2020Review
- Cytomegalovirus-specific CD8+ T-cell responses are associated with arterial blood pressure in people living with HIV.PloS one · 2020Article
- T-cell immunity against cytomegalovirus in HIV infection and aging: relationships with inflammation, immune activation, and frailty.Medical microbiology and immunology · 2019Review
- Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1.EBioMedicine · 2019Article
- Relationship Between T-Cell Responses to CMV, Markers of Inflammation, and Frailty in HIV-uninfected and HIV-infected Men in the Multicenter AIDS Cohort Study.The Journal of infectious diseases · 2018Article
- Cytomegalovirus-specific T-cells are associated with immune senescence, but not with systemic inflammation, in people living with HIV.Scientific reports · 2018Article
- Immune Dysfunction and Coinfection with Human Immunodeficiency Virus andJournal of immunology research · 2018Article
- Recent advances in CMV tropism, latency, and diagnosis during aging.GeroScience · 2017Article
- Suppressive effects of sirtinol on human cytomegalovirus (hCMV) infection and hCMV-induced activation of molecular mechanisms of senescence and production of reactive oxygen species.Mechanisms of ageing and development · 2016Article
- Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection.Current HIV/AIDS reports · 2016Review
- Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection.Frontiers in microbiology · 2016Review
- Interaction between unrelated viruses during in vivo co-infection to limit pathology and immunity.Virology · 2015Article
- The Sordid Affair Between Human Herpesvirus and HIV.The Journal of infectious diseases · 2015Review
- Physical function impairment of older, HIV-infected adults is associated with cytomegalovirus immunoglobulin response.AIDS research and human retroviruses · 2015Article
- Detecting Antigen-Specific T Cell Responses: From Bulk Populations to Single Cells.International journal of molecular sciences · 2015Review
- Understanding frailty, aging, and inflammation in HIV infection.Current HIV/AIDS reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Studies of T-cell immunity to human cytomegalovirus (CMV) primarily reflect anti-CMV pp65 or immediate early antigen 1 (IE-1) activity. We assessed responses of T cells from human immunodeficiency virus (HIV)-negative and HIV-infected men to peptide pools spanning 19 CMV open reading frames selected because they previously correlated with total CMV-specific T-cell responses in healthy donors. Cells producing cytokines in response to pp65 or IE-1 together composed <12% and <40% of the total CD4(+) and CD8(+) T-cell responses to CMV, respectively. These proportions were generally similar regardless of HIV serostatus. Thus, analyses of total CMV-specific T-cell responses should extend beyond pp65 and IE-1 regardless of HIV serostatus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.