ArticleThe Plant cell2014
Structural features determining flower-promoting activity of Arabidopsis FLOWERING LOCUS T.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 133 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
133 citing papers in PubMed.
- A mutant allele of the long-day floral activator NtFT5 is associated with the short-day-specific flowering of tobacco cultivar Maryland Mammoth.Communications biology · 2026Article
- Adaptive genomic signatures in PEBP genes reveal flowering plasticity and ecological specialization in Orchidaceae.Plant communications · 2026Article
- Remodeling of the tuberization-controlling FLOWERING LOCUS T genes from non-tuberizing ancestor to potato.The Plant journal : for cell and molecular biology · 2026Article
- Genome-Wide Analysis of the PEBP Gene Family and Functional Characterization ofInternational journal of molecular sciences · 2026Article
- Characterization of TERMINAL FLOWER 1 homologs from Macroptilium (Benth.) Urb.Plant reproduction · 2026Article
- Regulation of developmental transitions in plants: the role of VIVAPAROUS ABI3-LIKE (VAL) repressors.Journal of plant research · 2026Review
- Identification, evolution, and expression analysis of the PEBP gene family in tobacco (Nicotiana tabacum) and its role in flowering regulation via interaction with 14-3-3 proteins.BMC plant biology · 2026Article
- Genome-Wide Identification and Expression Analysis of the PEBP Gene Family inPlants (Basel, Switzerland) · 2026Article
- Article
- Multiplexed profiling of transcriptional regulators in plant cells.Nature biotechnology · 2025Article
- FT-like genes in Cannabis and hops: sex specific expression and copy-number variation may explain flowering time variation.BMC genomics · 2025Article
- Florigen and Florigen-Like Genes Regulate Temperature-Responsive Flowering in Tomato.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Integration of signals inducing reproductive phase transition occurs at the nodal enlarged vascular bundles in sacred lotus, Nelumbo nucifera.Plant & cell physiology · 2025Article
- Mechanisms driving functional divergence of transcription factor paralogs.The New phytologist · 2025Review
- Article
- Florigen and antiflorigen gene expression correlates with reproductive state in a marine angiosperm,iScience · 2025Article
- Flowering Initiation Genes Determine the Node for Inflorence-Ear in Zea Mays L.Doklady. Biochemistry and biophysics · 2025Article
- Article
- Molecular Characterization ofGenes · 2025Article
- Dancing molecules: group A bZIPs and PEBPs at the heart of plant development and stress responses.Journal of experimental botany · 2025Review
73 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issuedCORRECTION.2020
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Arabidopsis thaliana, the genes FLOWERING LOCUS T (FT) and TERMINAL FLOWER1 (TFL1) have antagonistic roles in regulating the onset of flowering: FT activates and TFL1 represses flowering. Both encode small, closely related transcription cofactors of ∼175 amino acids. Previous studies identified a potential ligand binding residue as well as a divergent external loop as critical for the differences in activity of FT and TFL1, but the mechanisms for the differential action of FT and TFL1 remain unclear. Here, we took an unbiased approach to probe the importance of residues throughout FT protein, testing the effects of hundreds of mutations in vivo. FT is surprisingly robust to a wide range of mutations, even in highly conserved residues. However, specific mutations in at least four different residues are sufficient to convert FT into a complete TFL1 mimic, even when expressed from TFL1 regulatory sequences. Modeling the effects of these mutations on the surface charge of FT protein suggests that the affected residues regulate the docking of an unknown ligand. These residues do not seem to alter the interaction with FD or 14-3-3 proteins, known FT interactors. Potential candidates for differential mediators of FT and TFL1 activities belong to the TCP (for TEOSINTE BRANCHED1, CYCLOIDEA, PCF) family of transcription factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.