ArticleJournal of immunology (Baltimore, Md. : 1950)2014
Regulatory T cells limit induction of protective immunity and promote immune pathology following intestinal helminth infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 54 citations in OpenAlex.
- T cell exhaustion in parasitic infections.Frontiers in immunology · 2026Review
- Single-cell transcriptomics unveils leukocyte heterogeneity in the gills ofFrontiers in immunology · 2025Article
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- CsHscB Derived from a Liver FlukeCurrent molecular medicine · 2024Article
- Near-infrared spectroscopy and machine learning algorithms for rapid and non-invasive detection of Trichuris.PLoS neglected tropical diseases · 2023Article
- Interaction between tissue-dwelling helminth and the gut microbiota drives mucosal immunoregulation.NPJ biofilms and microbiomes · 2023Article
- The Immune Response to Nematode Infection.International journal of molecular sciences · 2023Review
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- Gut Helminth Infection-Induced Immunotolerance and Consequences for Human Papillomavirus Persistence.The American journal of tropical medicine and hygiene · 2021Review
- The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function.Communications biology · 2021Article
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- Review
- Elucidating different pattern of immunoregulation in BALB/c and C57BL/6 mice and their F1 progeny.Scientific reports · 2021Article
- Mechanism by which the combination of SjCL3 and SjGAPDH protects against Schistosoma japonicum infection.Parasitology research · 2021Article
- Investigating the importance of B cells and antibodies during Trichuris muris infection using the IgMi mouse.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Regulatory T-cells in helminth infection: induction, function and therapeutic potential.Immunology · 2020Review
- Immunomodulatory effect of Syphacia obvelata in treatment of experimental DSS-induced colitis in mouse model.Scientific reports · 2019Article
- Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8Immunity · 2019Article
- Interplay between proinflammatory cytokines, miRNA, and tissue lesions in Anisakis-infected Sprague-Dawley rats.PLoS neglected tropical diseases · 2019Article
- Helminthiases; prevalence, transmission, host-parasite interactions, resistance to common synthetic drugs and treatment.Heliyon · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Foxp3(+) regulatory T cells (Tregs) have a well-characterized role in limiting autoimmunity and dampening deleterious immune responses. However, a potential consequence of the immunosuppressive function of Tregs can be the limitation of protective immunity to infectious pathogens. Parasitic infections are a potent stimulus for the generation of Treg responses, which may be beneficial to both the parasite and the host by promoting persistence of infection and limiting immune-mediated pathology, respectively. In this study, we explore the functional role of Tregs post-low-dose infection with the intestinal helminth parasite Trichuris muris, which yields a chronic infection because of inefficient induction of Th2 responses. Early Treg depletion postinfection resulted in expedited worm clearance, and was associated with reduced Th1-mediated inflammation of the intestinal environment. Interestingly, this protective immunity was lost, and worm burden enhanced if Tregs were depleted later once the infection was established. Early and late Treg depletion resulted in enhanced Th2 and reduced Th1 cytokine and humoral responses. Blockade of the Th2 cytokine IL-4 resulted in a moderate increase in Th1 but had no effect on worm burden. Our findings suggest that Tregs preferentially limit Th2 cell expansion, which can impact infections where clear immune polarity has not been established. Thus, the impact of Treg depletion is context and time dependent, and can be beneficial to the host in situations where Th1 responses should be limited in favor of Th2 responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.