ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Genetic association of CHEK2, GSTP1, and ERCC1 with glioblastoma in the Han Chinese population.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Association between common polymorphisms in ERCC gene and glioma risk: A meta-analysis of 15 studies.Medicine · 2017Pooled it
- Polymorphisms in DNA Repair Gene and Susceptibility to Glioma: A Systematic Review and Meta-Analysis Based on 33 Studies with 15 SNPs in 9 Genes.Cellular and molecular neurobiology · 2017Pooled it
- A Comprehensive Analysis of Influence ERCC Polymorphisms Confer on the Development of Brain Tumors.Molecular neurobiology · 2016Pooled it
- Genetic Contribution of Polymorphisms in Glutathione S-Transferases to Brain Tumor Risk.Molecular neurobiology · 2016Pooled it
- Effect of CDKN2A/B rs4977756 polymorphism on glioma risk: a meta-analysis of 16 studies including 24077 participants.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Pooled it
- Single-Nucleotide Polymorphisms Related to Glioblastoma Risk and Worldwide Epidemiology: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2025Review
- Explainable Machine Learning Models for Glioma Subtype Classification and Survival Prediction.Cancers · 2025Article
- Review
- Article
- ERCC2 rs13181 Polymorphism Association with Glioma Risk: an Update Meta-Analysis.Indian journal of surgical oncology · 2023Review
- Contribution of CYP24A1 variants in coronary heart disease among the Chinese population.Lipids in health and disease · 2020Article
- LPP and RYR2 Gene Polymorphisms Correlate with the Risk and the Prognosis of Astrocytoma.Journal of molecular neuroscience : MN · 2019Article
- Glutathione S-transferase genes variants and glioma risk: A case-control and meta-analysis study.Journal of Cancer · 2019Article
- Genetics of Glioblastoma in Moroccan population: Review of literature.IBRO reports · 2018Review
- Gene expression profiling by mRNA array reveals different pattern in Chinese glioblastoma patients between Uygur and Han populations.International journal of clinical and experimental medicine · 2015Article
- DNA repair gene ERCC1 polymorphisms and glioma susceptibility among Chinese population: a meta-analysis.International journal of clinical and experimental medicine · 2015Review
- Differential expression and clinical significance of glioblastoma mRNA expression profiles in Uyghur and Han patients in Xinjiang province.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Association of ERCC1 rs3212986 & ERCC2 rs13181 polymorphisms with the risk of glioma.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioblastoma (GBM), a deadly brain tumor, is the most malignant glioma. It mainly occurs in adults and occurs significantly more in males than in females. We genotyped 19 tag single nucleotide polymorphisms (tSNPs) from 13 genes in a case-control study of the Han Chinese population to identify genetic factors contributing to the risk of GBM. These tSNPs were genotyped by Sequenom MassARRAY RS1000. Statistical analysis was performed using χ(2) test and SNPStats, a website software. Using χ(2) test, we found that the distribution of two tSNPs (rs2267130 in checkpoint kinase 2 (CHEK2), p = 0.040; rs1695 in GSTP1, p = 0.023) allelic frequencies had significant difference between cases and controls. When we analyzed all of the tSNPs using the SNPStats software, we found that rs1695 in GSTP1 decreased the risk of GBM in log-additive model (OR = 0.56, 95% CI, 0.34-0.94, p = 0.022). Besides, we found that there is an interaction between rs3212986 in excision repair cross-complementing group 1 (ERCC1) and gender under codominant and recessive models. The gene polymorphisms in CHEK2, GSTP1, and ERCC1 may be involved in GBM in the Han Chinese population. Since our sample size is small, further investigation needs to be performed.
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