ArticleJournal of endocrinological investigation2014
Lipodystrophy syndrome in HIV treatment-multiexperienced patients: implication of resistin.
Article in Journal of endocrinological investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Vitamin D Status in People Living with HIV: Assessment of 25(OH)D Levels and Associated Factors-A Cross-Sectional Study.Metabolites · 2026Article
- Effects of rilpivirine, 17β-estradiol and β-naphthoflavone on the inflammatory status of release of adipocytokines in 3T3-L1 adipocytes in vitro.Molecular biology reports · 2019Article
- Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro.Diabetes & vascular disease research · 2018Article
- Adipokines and bone metabolism: an interplay to untangle.Journal of endocrinological investigation · 2016Article
- Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users.Endocrine connections · 2015Article
- Human resistin and the RELM of Inflammation in diabesity.Diabetology & metabolic syndrome · 2015Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired production of adipocytokines is a major factor incriminated in the occurrence of lipodystrophy (LD).
objectiveTo evaluate LD prevalence and subtypes in HIV treatment-multiexperienced patients, and to determine the correlations between adipocytokines and LD subtypes.
methodsCross-sectional study in a Romanian tertiary care hospital, between 2008 and 2010, in HIV-positive patients, undergoing cART for ≥6 months. LD diagnosis, based on clinical and anthropometric data, was classified into lipoatrophy (LA), lipohypertrophy (LH) and mixed fat redistribution (MFR). Blood samples were collected for leptin, adiponectin and resistin assessments.
resultsWe included 100 patients, 44 % with LD, among which LA had 63 %. LA patients had sex ratio, median age, treatment duration and median number of ARV regimens of 1, 20, 93 and 3.5 compared to non-LD patients: 1.65, 31, 44 and 1. LH and MFR patients were older and had higher total and LDL cholesterol versus non-LD patients. For both overall group and female group, LA was associated in univariate and multivariate analysis with increased resistin (p = 0.02 and 0.04) and number of ARV regimens (p < 0.001). Determination coefficient (Nagelkerke R (2)) of increased resistin and the number of ARV combinations in the presence of LA was 33 % in overall group and 47 % in female patients.
conclusionsIn our young HIV-positive population, LD had high prevalence with predominance of LA subtype. LA was associated with high resistin levels and greater number of ARV regimens in overall group and female subgroup. Resistin could be used as a marker of peripheral adipose tissue loss and might be used as a target for new anti-LD therapeutic strategies.
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