ArticleJournal of neuro-oncology2014
Analysis of KIAA1549-BRAF fusion gene expression and IDH1/IDH2 mutations in low grade pediatric astrocytomas.
Article in Journal of neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- BRAF Mutation is Associated with an Improved Survival in Glioma-a Systematic Review and Meta-analysis.Molecular neurobiology · 2018Pooled it
- Article
- Low-grade epilepsy-associated neuroepithelial tumors: Tumor spectrum and diagnosis based on genetic alterations.Frontiers in neuroscience · 2022Review
- Molecular alterations in the integrated diagnosis of pediatric glial and glioneuronal tumors: A single center experience.PloS one · 2022Article
- IDH-mutant gliomas with additional class-defining molecular events.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Evaluating pediatric spinal low-grade gliomas: a 30-year retrospective analysis.Journal of neuro-oncology · 2019Article
- Anaplastic glioneuronal tumor withIntractable & rare diseases research · 2019Article
- Recent Progress in the Pathology and Genetics of Pilocytic and Pilomyxoid AstrocytomasBalkan medical journal · 2019Article
- Oligodendrogliomas in pediatric and teenage patients only rarely exhibit molecular markers and patients have excellent survivals.Journal of neuro-oncology · 2018Article
- Clinical prognostic value of the isocitrate dehydrogenase 1 single-nucleotide polymorphism rs11554137 in glioblastoma.Journal of neuro-oncology · 2018Article
- Pediatric High Grade Gliomas in the Context of Cancer Predisposition Syndromes.Journal of Korean Neurosurgical Society · 2018Review
- An integrative molecular and genomic analysis of pediatric hemispheric low-grade gliomas: an update.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
- Frequency of BRAF V600E mutations in 969 central nervous system neoplasms.Diagnostic pathology · 2016Article
- Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology.Acta neuropathologica · 2016Article
- Analysis of IDH1-R132 mutation, BRAF V600 mutation and KIAA1549-BRAF fusion transcript status in central nervous system tumors supports pediatric tumor classification.Journal of cancer research and clinical oncology · 2016Article
- Current Understanding of BRAF Alterations in Diagnosis, Prognosis, and Therapeutic Targeting in Pediatric Low-Grade Gliomas.Frontiers in oncology · 2015Review
- Molecular Profiling of a Rare Rosette-Forming Glioneuronal Tumor Arising in the Spinal Cord.PloS one · 2015Article
- A Comprehensive Method for Detecting Fusion Genes in Paediatric Brain Tumours.Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low-grade astrocytomas comprise about 30 % of the central nervous system tumors in children. Several investigations have searched a correlation between the BRAF gene fusions alterations and mutations at IDH1 and IDH2 genes in low grade pediatric astrocytomas. This study identified the expression of KIAA1549-BRAF fusion gene and BRAF V600E mutation, mutations at exon 4 of the IDH1 and IDH2 genes in samples of pilocytic astrocytomas (PA) and grade-II astrocytomas (A-II) pediatric patients. The correlation between these alterations and the clinical profile of the patients was also evaluated. Eighty-two samples of low-grade astrocytomas (65 PA and 17 A-II) were analyzed by PCR and sequencing for each of the targets identified. We identified the KIAA1549-BRAF fusion transcript in 45 % of the samples. BRAF V600E and BRAFins598T mutations were detected in 7 and 1 % of the samples, respectively. Mutations in the R132/R172 residues of the IDH1/IDH2 genes were detected in only two samples, and the G105G polymorphism (rs11554137:C>T) was identified in ten patients. Additionally, we observed two mutations out of the usual hotspots at IDH1 and IDH2 genes. We observed a smaller frequency of mutations in IDHs genes than previously described, but since the prior studies were composed of adult or mixed (adults and children) samples, we believe that our results represent a relevant contribution to the growing knowledge in low grade childhood astrocytomas.
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