ArticleJournal of neurology2014
Is the incidence of optic neuritis rising? Evidence from an epidemiological study in Barcelona (Spain), 2008-2012.
Article in Journal of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Demographic and Epidemiological Profile of Optic Neuritis in Colombia: A Retrospective Study Using Data from the Comprehensive Information System for Social Protection.Neuro-ophthalmology (Aeolus Press) · 2026Article
- Prevalence of pediatric and adult optic neuritis in the United States from 2016 to 2023.Eye (London, England) · 2025Article
- Retinal Damage and Visual Network Reconfiguration Defines Visual Function Recovery in Optic Neuritis.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Review
- Pregnancy prevalence and outcomes after optic neuritis in South Korea.Scientific reports · 2023Article
- The pathological mechanisms and novel therapeutics for Leber's hereditary optic neuropathy.Journal of the Chinese Medical Association : JCMA · 2023Article
- [Optic neuritis: aetiopathogenesis, diagnosis, prognosis and management].Revista de neurologia · 2022Review
- Neurological autoimmune diseases following vaccinations against SARS-CoV-2: a case series.European journal of neurology · 2022Article
- The changing landscape of optic neuritis: a narrative review.Journal of neurology · 2022Review
- Update on Optic Neuritis: An International View.Neuro-ophthalmology (Aeolus Press) · 2022Review
- Emerging concepts in the treatment of optic neuritis: mesenchymal stem cell-derived extracellular vesicles.Stem cell research & therapy · 2021Review
- Incidence Rates of Autoimmune Diseases in European Healthcare Databases: A Contribution of the ADVANCE Project.Drug safety · 2021Article
- Comprehensive review of neuromyelitis optica and clinical characteristics of neuromyelitis optica patients in Puerto Rico.Surgical neurology international · 2018Review
- Recurrent isolated optic neuritis: A study on 22 patients.Iranian journal of neurology · 2017Article
- Melatonin as a Therapeutic Resource for Inflammatory Visual Diseases.Current neuropharmacology · 2017Review
- Visual field impairment captures disease burden in multiple sclerosis.Journal of neurology · 2016Article
- Vision and vision-related outcome measures in multiple sclerosis.Brain : a journal of neurology · 2015Review
- Acute Optic Neuritis: An Update on Approach and Management.Journal of ophthalmic & vision researchReview
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is currently believed that the incidence rate of optic neuritis (ON) ranges between 0.56 and 5.1 cases per 100,000 person-years. However, since these figures were generated, they have not been updated and there are suggestions that the incidence of ON is on the rise. When designing new therapies and clinical trials for ON, and to improve the management this disease, it is important to have accurate epidemiological data. Thus, we set out to obtain the prevalence and incidence rates of ON in Barcelona (Spain) from 2008 to 2012, by a retrospective evaluation of electronic hospital records at the Hospital Clinic of Barcelona (population of 300,000 in the catchment area) matching the following ICD-9-CM codes as search terms: 377.3-optic neuritis; 377.30-optic neuritis, unspecific; 377.31-optic papillitis; 377.32-retrobulbar neuritis, acute; 377.39-other optic neuritis and "optic neuropathy". Demographic and clinical data were collected from records with a confirmed diagnosis of ON, including cases of idiopathic ON, multiple sclerosis, neuromyelitis optica and CRION. The prevalence of acute ON on 31 December 2012 was 2.75 cases per 100,000 people. The mean annual prevalence of acute ON during the 2008-2012 period was 7.87 cases per 100,000 person-year and the mean annual incidence rate was 5.36 cases per 100,000 person-years. The incidence of ON in Barcelona during 2008-2012 was higher than previously reported. This increase may reflect the evolution of diagnostic criteria, the use of a referral-center approach instead of a population-based approach, increased awareness of demyelinating diseases, latitude-related factors and possibly a true increase in its incidence.
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