Evidence map›Paper›PMID 24532143›Full record

Trial reportSurgery today2014

Haloperidol prophylaxis does not prevent postoperative delirium in elderly patients: a randomized, open-label prospective trial.

Shinji Fukata, Yasuji Kawabata, Ken Fujisiro, Yuichi Katagawa, Kojiro Kuroiwa, Hirotoshi Akiyama, Yasuhito Terabe, Masahiko Ando, Takashi Kawamura, Hideyuki Hattori

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgery today, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03199950 (Delirium), which is not on this map. Cited by 21 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 7 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03199950 phase4unknown statusnot on this mapstarted 2017, after this paper: background citation

Delirium: Is Prophylactic Drug Therapy Useful in High Risk Patients as Defined by the Delirium Risk Prediction Model?

TypeinterventionalSponsorZuyderland Medisch CentrumRan2017 to 2018Enrolled1,366ConditionsDeliriumArmsHaloperidol, Placebo Oral Tablet
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 7 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Hospital Elder Life Program: Systematic Review and Meta-analysis of Effectiveness.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018
    Pooled it
  6. Effects of Haloperidol on Delirium in Adult Patients: A Systematic Review and Meta-Analysis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018
    Pooled it
  7. Interventions for preventing delirium in hospitalised non-ICU patients.The Cochrane database of systematic reviews · 2016
    Pooled it
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Antipsychotic Drugs in Prevention of Postoperative Delirium-What Is Known in 2020?International journal of environmental research and public health · 2020
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Shinji FukataDepartment of Surgery, National Center for Geriatrics and Gerontology, Obu, Japan, fukatash@ncgg.go.jp.
Yasuji Kawabata
Ken Fujisiro
Yuichi Katagawa
Kojiro Kuroiwa
Hirotoshi Akiyama
Yasuhito Terabe
Masahiko Ando
Takashi Kawamura
Hideyuki Hattori
National Center for Geriatrics and Gerontology · JPKyoto University · JPNagoya University · JPTokyo Metropolitan Geriatric Hospital · JPYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePostoperative delirium is the most common postoperative complication in the elderly. The purpose of this study was to evaluate the safety and effectiveness of the preventive administration of low-dose haloperidol on the development of postoperative delirium after abdominal or orthopedic surgery in elderly patients. SUBJECTS: A total of 119 patients aged 75 years or older who underwent elective surgery for digestive or orthopedic disease were included in this study.

methodsPatients were divided into those who did (intervention group, n = 59) and did not (control group, n = 60) receive 2.5 mg of haloperidol at 18:00 daily for 3 days after surgery; a randomized, open-label prospective study was performed on these groups. The primary endpoint was the incidence of postoperative delirium during the first 7 days after the operation.

resultsThe incidence of postoperative delirium in all patients was 37.8%. No side effects involving haloperidol were noted; however, the incidences of postoperative delirium were 42.4 and 33.3% in the intervention and control groups, respectively, which were not significantly different (p = 0.309). No significant effect of the treatment was observed on the severity or persistence of postoperative delirium.

conclusionsThe preventive administration of low-dose haloperidol did not induce any adverse events, but also did not significantly decrease the incidence or severity of postoperative delirium or shorten its persistence.

Indexed as

AgedAged, 80 and overAntipsychotic AgentsDeliriumDigestive System Surgical ProceduresElective Surgical ProceduresFemaleHaloperidolHumansIncidenceMaleOrthopedic ProceduresPostoperative ComplicationsProspective StudiesAntipsychotic AgentsHaloperidol

Identifiers

PMID24532143
OpenAlexW2111711625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.