ArticleMovement disorders : official journal of the Movement Disorder Society2014
Essential tremor is not associated with cerebellar Purkinje cell loss.
Article in Movement disorders : official journal of the Movement Disorder Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Imaging the Pathophysiology of Essential Tremor-A Systematic Review.Frontiers in neurology · 2021Pooled it
- No reliable gray matter changes in essential tremor.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- Neuroimaging essentials in essential tremor: a systematic review.NeuroImage. Clinical · 2014Pooled it
- Association between mild action tremor and cognition in community dwelling older adults: results from the KORA-Age study.Journal of neurology · 2026Article
- Single-cell expression QTL analyses of the human cerebellum reveal vulnerability of oligodendrocytes in essential tremor.Nature genetics · 2026Article
- Viral vector-mediated SLC9A6 gene replacement reduces cerebellar motor and molecular abnormalities in the shaker rat model of Christianson syndrome.Human molecular genetics · 2026Article
- Degenerative Changes in the Essential Tremor Cerebellum.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Comparative study of the pathology in anterior versus posterior hemispheric regions of cerebellum in essential tremor and controls.Acta neuropathologica · 2026Article
- Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21-Year Period.Annals of clinical and translational neurology · 2026Article
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Cerebellum and Aging: Update and Challenges.Aging and disease · 2024Review
- Six Myths and Misconceptions about Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Review
- Visuomotor Adaptation Deficits in Patients with Essential Tremor.Cerebellum (London, England) · 2023Article
- Lack of significant Lewy pathology in 237 essential tremor brains.Journal of neuropathology and experimental neurology · 2023Article
- GABA-A Alpha 2/3 but Not Alpha 1 Receptor Subunit Ligand Inhibits Harmaline and Pimozide-Induced Tremor in Rats.Biomolecules · 2023Article
- Postmortem Cerebellar Volume Is Not Reduced in Essential Tremor: A Comparison with Multiple System Atrophy and Controls.Journal of Parkinson's disease · 2023Article
- Morphological and morphometric changes in the Purkinje cells of patients with essential tremor.Experimental and therapeutic medicine · 2022Article
- A standardized accelerometry method for characterizing tremor: Application and validation in an ageing population with postural and action tremor.Frontiers in neuroinformatics · 2022Article
- Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder.International review of neurobiology · 2022Article
- The Pathophysiology and Treatment of Essential Tremor: The Role of Adenosine and Dopamine Receptors in Animal Models.Biomolecules · 2021Review
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8 authors at 2 institutions in 1 country.
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Abstract
There has been controversy as to whether there is an underlying neurodegenerative process of the cerebellum in essential tremor (ET). The aim of this study was to examine whether ET is associated with Purkinje cell (PC) loss. Prospectively categorized ET and control subjects who were longitudinally examined in the Arizona Study for Aging and Neurodegenerative Disorders and came to autopsy between 1998 and 2013 underwent standardized neuropathological assessment of the brain. PC linear density of the cerebellar hemisphere was calculated in a blinded manner. There were 56 ET cases and 62 age-matched controls free of dementia and other neurodegenerative disorders included in the study. Mean PC linear density was 3.80 ± 0.81 cells per mm for tremor cases and 3.82 ± 0.91 cells per mm for controls (Δ 0.02; 95% confidence interval [CI]: -0.30-0.34). PC counts were not associated with tremor duration (r = 0.06; 95% CI: -0.21-0.32). These data demonstrate that ET is not associated with cerebellar PC loss.
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