ArticleApplied and environmental microbiology2014
Role of the Alternaria alternata blue-light receptor LreA (white-collar 1) in spore formation and secondary metabolism.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Article
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- Regulation and induction of fungal secondary metabolites: a comprehensive review.Archives of microbiology · 2025Review
- Light regulation of secondary metabolism in fungi.Journal of biological engineering · 2023Review
- Light in the box-photobiological examination chamber with light trap ventilation system for studying fungal surface cultures illustrated with Metarhizium brunneum and Beauveria brongniartii.Fungal biology and biotechnology · 2023Article
- Overview of fungal terpene synthases and their regulation.World journal of microbiology & biotechnology · 2023Review
- Tuning the Wavelength: Manipulation of Light Signaling to Control Plant Defense.International journal of molecular sciences · 2023Review
- Biocontrol potential of lipopeptides produced by the novelFrontiers in microbiology · 2023Article
- How to Completely Squeeze a Fungus-Advanced Genome Mining Tools for Novel Bioactive Substances.Pharmaceutics · 2022Review
- Roles of AaFrontiers in microbiology · 2022Article
- Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds.Journal of fungi (Basel, Switzerland) · 2021Review
- Asexual reproduction and vegetative growth ofEcology and evolution · 2021Article
- Transcription factor control of virulence in phytopathogenic fungi.Molecular plant pathology · 2021Review
- The wheat pathogen Zymoseptoria tritici senses and responds to different wavelengths of light.BMC genomics · 2020Article
- Blakeslea trispora Photoreceptors: Identification and Functional Analysis.Applied and environmental microbiology · 2020Article
- The Photoreceptor Components FaWC1 and FaWC2 ofMicroorganisms · 2020Article
- The Blue-Light PhotoreceptorApplied and environmental microbiology · 2019Article
- Interaction with Pantoea agglomerans Modulates Growth and Melanization of Sporothrix brasiliensis and Sporothrix schenckii.Mycopathologia · 2019Article
- Article
- Fungal secondary metabolism: regulation, function and drug discovery.Nature reviews. Microbiology · 2019Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alternaria alternata is a filamentous fungus that causes considerable loss of crops of economically important feed and food worldwide. It produces more than 60 different secondary metabolites, among which alternariol (AOH) and altertoxin (ATX) are the most important mycotoxins. We found that mycotoxin production and spore formation are regulated by light in opposite ways. Whereas spore formation was largely decreased under light conditions, the production of AOH was stimulated 2- to 3-fold. ATX production was even strictly dependent on light. All light effects observed could be triggered by blue light, whereas red light had only a minor effect. Inhibition of spore formation by light was reversible after 1 day of incubation in the dark. We identified orthologues of genes encoding the Neurospora crassa blue-light-perceiving white-collar proteins, a cryptochrome, a phytochrome, and an opsin-related protein in the genome of A. alternata. Deletion of the white-collar 1 (WC-1) gene (lreA) resulted in derepression of spore formation in dark and in light. ATX formation was strongly induced in the dark in the lreA mutant, suggesting a repressing function of LreA, which appears to be released in the wild type after blue-light exposure. In addition, light induction of AOH formation was partially dependent on LreA, suggesting also an activating function. A. alternata ΔlreA was still able to partially respond to blue light, indicating the action of another blue-light receptor system.
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