ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
CT-based attenuation correction in Tl-201 myocardial perfusion scintigraphy is less effective than non-corrected SPECT for risk stratification.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 14 citations in OpenAlex.
- Deep Learning-Based Automated Diagnosis for Coronary Artery Disease Using SPECT-MPI Images.Journal of clinical medicine · 2022Article
- CT Attenuation correction and its impact on image quality of myocardial perfusion imaging in coronary artery disease: A systematic review.Asia Oceania journal of nuclear medicine & biology · 2021Review
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundPrevious studies advocate the use of attenuation correction in myocardial perfusion scintigraphy (MPS) for patient risk stratification.
methodsSix-hundred and thirty-seven unselected patients underwent Tl-201 MPS by a hybrid SPECT/CT system. Attenuation-corrected (AC) and non-corrected (NAC) images were interpreted blindly and summed stress scores (SSS) were calculated. Study endpoints were all-cause mortality and the composites of death/non-fatal acute myocardial infarction (AMI) and death/AMI/late revascularization.
resultsDuring a follow-up of 42.3 ± 12.8 months 24 deaths, 13 AMIs and 28 revascularizations were recorded. SSS groups formed according to event rate distribution across SSS values were: 0-4, 5-13, >13 for NAC and 0-2, 3-9, >9 for AC. Kaplan-Meier functions were statistically significant between NAC SSS groups for all study endpoints. AC discriminated only between SSS 0-2 and >9 for death/AMI and between 0-2 and 3-9 for death/AMI/revascularization. In the univariate Cox regression abnormal NAC (SSS > 4) was accompanied with much higher hazards ratios than abnormal AC (SSS > 2). In the multivariate model abnormal AC yielded no significance for either endpoint whereas abnormal NAC proved independent from other covariates for the composite endpoints.
conclusionOur results challenge the effectiveness of CT-based AC for risk stratification of patients referred for MPS.
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