ArticleHuman brain mapping2014
Frontostriatal activity and connectivity increase during proactive inhibition across adolescence and early adulthood.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Evidence for non-selective response inhibition in uncertain contexts revealed by combined meta-analysis and Bayesian analysis of fMRI data.Scientific reports · 2022Pooled it
- Large-scale functional neural network correlates of response inhibition: an fMRI meta-analysis.Brain structure & function · 2017Pooled it
- Trial
- Sex differences in tobacco smokers: Executive control network and frontostriatal connectivity.Drug and alcohol dependence · 2019Trial
- Has stopping stopped making sense? Disentangling the processes elicited by complex action cancellation paradigms.Cognitive, affective & behavioral neuroscience · 2026Review
- Protracted Maturation of Proactive and Reactive Systems Predicts Cognitive Stability and Psychopathology : A longitudinal multi-cohort study.bioRxiv : the preprint server for biology · 2026Article
- Dynamic modeling in neurocognitive frameworks of childhood ADHD: a review of inhibitory control and reward systems.Translational psychiatry · 2026Review
- Frontal theta power prospectively associated with response inhibition.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Triple network dynamics and future alcohol consumption in adolescents.Alcohol, clinical & experimental research · 2025Article
- Examining the association among adolescents' emotional clarity, emotion differentiation, and the regulation of negative and positive affect using a daily diary approach.Emotion (Washington, D.C.) · 2025Article
- Age-related changes in pupil dynamics and task modulation across the healthy lifespan.Frontiers in neuroscience · 2024Article
- Resting-state functional MRI study of conventional MRI-negative intractable epilepsy in children.Frontiers in human neuroscience · 2024Article
- Task-Based Functional Connectivity in Attention-Deficit/Hyperactivity Disorder: A Systematic Review.Biological psychiatry global open science · 2022Review
- OSARI, an Open-Source Anticipated Response Inhibition Task.Behavior research methods · 2022Article
- The Asymmetric Laplace Gaussian (ALG) Distribution as the Descriptive Model for the Internal Proactive Inhibition in the Standard Stop Signal Task.Brain sciences · 2022Article
- Contributions of dopamine-related basal ganglia neurophysiology to the developmental effects of incentives on inhibitory control.Developmental cognitive neuroscience · 2022Article
- Growth trajectories of cognitive and motor control in adolescence: How much is development and how much is practice?Neuropsychology · 2022Article
- Functional changes of the prefrontal cortex, insula, caudate and associated cognitive impairment (chemobrain) in NSCLC patients receiving different chemotherapy regimen.Frontiers in oncology · 2022Article
- Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis.Frontiers in aging neuroscience · 2022Article
- Developing adaptive control: Age-related differences in task choices and awareness of proactive and reactive control demands.Cognitive, affective & behavioral neuroscience · 2021Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During adolescence, functional and structural changes in the brain facilitate the transition from childhood to adulthood. Because the cortex and the striatum mature at different rates, temporary imbalances in the frontostriatal network occur. Here, we investigate the development of the subcortical and cortical components of the frontostriatal network from early adolescence to early adulthood in 60 subjects in a cross-sectional design, using functional MRI and a stop-signal task measuring two forms of inhibitory control: reactive inhibition (outright stopping) and proactive inhibition (anticipation of stopping). During development, reactive inhibition improved: older subjects were faster in reactive inhibition. In the brain, this was paralleled by an increase in motor cortex suppression. The level of proactive inhibition increased, with older subjects slowing down responding more than younger subjects when anticipating a stop-signal. Activation increased in the right striatum, right ventral and dorsal inferior frontal gyrus, and supplementary motor area. Moreover, functional connectivity during proactive inhibition increased between striatum and frontal regions with age. In conclusion, we demonstrate that developmental improvements in proactive inhibition are paralleled by increases in activation and functional connectivity of the frontostriatal network. These data serve as a stepping stone to investigate abnormal development of the frontostriatal network in disorders such as schizophrenia and attention-deficit hyperactivity disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.