ReviewPediatric cardiology2014
Beyond a broken heart: circulatory dysfunction in the failing Fontan.
Review in Pediatric cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Efficacy of Bosentan in patients after Fontan procedures: a double-blind, randomized controlled trial.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Trial
- Risk Factors for Adverse Outcomes in a Fontan Population.Pediatric cardiology · 2026Article
- Transcatheter fenestration in Fontan failure: Our clinical experience.Turk gogus kalp damar cerrahisi dergisi · 2025Article
- Case report and review of the literature: Successful transition from acute continuous veno-venous hemodiafiltration therapy to chronic peritoneal dialysis in a chronically ventilated child with hypoplastic left heart syndrome following fontan.Frontiers in pediatrics · 2022Article
- Pulmonary vascular disease in Fontan circulation-is there a rationale for pulmonary vasodilator therapies?Cardiovascular diagnosis and therapy · 2021Review
- Systemic Artery Vasoconstrictor Therapy in Fontan Patients with High Cardiac Output-Heart Failure: A Single-Center Experience.Pediatric cardiology · 2021Article
- Hepatic magnetic resonance T1-mapping and extracellular volume fraction compared to shear-wave elastography in pediatric Fontan-associated liver disease.Pediatric radiology · 2021Article
- Malnutrition and chyle leakage: A life-threatening duo in heart transplantation post-Fontan procedure.Clinical case reports · 2020Article
- Imaging of complications following Fontan circulation in children - diagnosis and surveillance.Pediatric radiology · 2020Review
- Prevalence of Short Stature and Growth Hormone Deficiency and Factors Associated With Short Stature After Fontan Surgery.Circulation reports · 2020Article
- Acute Hemodynamic Effects of Negative Extrathoracic Pressure in Fontan Physiology.Pediatric cardiology · 2019Article
- Emerging clinical applications of strain imaging and three-dimensional echocardiography for the assessment of ventricular function in adult congenital heart disease.Cardiovascular diagnosis and therapy · 2019Review
- Increased extracellular volume in the liver of pediatric Fontan patients.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019Article
- Magnetic Resonance Imaging Assessment of Blood Flow Distribution in Fenestrated and Completed Fontan Circulation with Special Emphasis on Abdominal Blood Flow.Korean journal of radiology · 2019Article
- Multisite measurement of regional oxygen saturation in Fontan patients with and without protein-losing enteropathy at rest and during exercise.Pediatric research · 2019Article
- Single-center experience of hemodialysis in patients after Fontan palliation.International journal of cardiology. Heart & vasculature · 2018Article
- Preoperative Evaluation of Adult Congenital Heart Disease Patients for Non-cardiac Surgery.Current cardiology reports · 2018Review
- Where Is the "Optimal" Fontan Hemodynamics?Korean circulation journal · 2017Review
- Superior Mesenteric Arterial Flow Pattern is Associated with Major Adverse Events in Adults with Fontan Circulation.Pediatric cardiology · 2016Article
- Clinical Approaches to the Patient with a Failing Fontan Procedure.Current cardiology reports · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has been described previously. However, a significant proportion of adult Fontan patients who die or require heart transplantation do so with preserved ventricular function. The clinical deterioration in patients who have undergone Fontan palliation requires a broader view of circulatory dysfunction, one that takes into account the complex interaction of regulatory systems affecting hepatic, renal, and pulmonary blood flow, in addition to cardiac function. This review focuses primarily on the pathophysiology of multiple organ involvement in this circulatory dysfunction, with particular focus on the consequences of hepatic dysfunction and portal hypertension. The authors discuss hepatic perfusion, both in health and disease, and review the current understanding of liver histopathology and liver disease in adult Fontan patients and similar clinicopathologic states. They compare and contrast features of postsinusoidal portal hypertension with more typical adult cirrhotic disease. Finally, they delineate the related effects of portal hypertensive physiology on the systemic and pulmonary vasculature, the kidney, and the heart itself and discuss how these changes affect the care of the adult Fontan patient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.