ArticleInflammation2014
Assessment of inflammatory biomarkers and oxidative stress in pulmonary thromboembolism: follow-up results.
Article in Inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- L-Shaped Association of 24-Hour Urine Output with 3-Month and 1-Year All-Cause Mortality in Patients with Acute Pulmonary Embolism: A Retrospective Cohort Study.Journal of atherosclerosis and thrombosis · 2025Article
- Metabolic landscape in venous thrombosis: insights into molecular biology and therapeutic implications.Annals of medicine · 2024Review
- Rivaroxaban Combined with Atorvastatin Inhibits Acute Pulmonary Embolism by Promoting the Expression of NRF2/NQO1.Cardiovascular drugs and therapy · 2024Article
- Plasma Deoxycholic Acid Levels are Associated with Hemodynamic and Clinical Outcomes in Acute Pulmonary Embolism Patients.Cardiovascular toxicology · 2024Article
- Oxidative Status, Iron Plasma Levels in Venous Thrombosis Patients.Antioxidants (Basel, Switzerland) · 2024Article
- Oxidative stress in acute pulmonary embolism: emerging roles and therapeutic implications.Thrombosis journal · 2024Review
- Exploration on the effect of anserine on the alleviation of DVT and its molecular mechanism.Frontiers in pharmacology · 2024Article
- Importance of oxidative stress in the evaluation of acute pulmonary embolism severity.BMC pulmonary medicine · 2022Article
- Extensive Acute Lower Extremity Arterial Thrombosis: A Major Thrombus Formation Caused by COVID-19.Vascular specialist international · 2021Article
- Development and validation of a novel risk assessment model to estimate the probability of pulmonary embolism in postoperative patients.Scientific reports · 2021Article
- Bioinformatics-based study to detect chemical compounds that show potential as treatments for pulmonary thromboembolism.International journal of molecular medicine · 2019Article
- Pulmonary thrombosis in acute organophosphate poisoning-Case report and literature overview of prothrombotic preconditioning in organophosphate toxicity.Toxicology reports · 2019Article
- Resveratrol downregulates TNF-α-induced monocyte chemoattractant protein-1 in primary rat pulmonary artery endothelial cells by P38 mitogen-activated protein kinase signaling.Drug design, development and therapy · 2019Article
- Subclinical Atherosclerosis in Patients with Prior Pulmonary Thromboembolism.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2017Article
- Differential effect of mild and severe pulmonary embolism on the rat lung transcriptome.Respiratory research · 2016Article
- Gene Expression Profiling of Pulmonary Artery in a Rabbit Model of Pulmonary Thromboembolism.PloS one · 2016Article
- Upregulation of Inflammatory Cytokines in Pulmonary Embolism Using Biochip-Array Profiling.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Instability in circulation, hypoperfusion, hypoxia, and ischemia in pulmonary thromboembolism (PTE) may occur as a result of failure in pulmonary circulation. All these conditions cause inflammation and oxidative stress. We aimed to investigate inflammatory markers, asymmetric dimethylarginine (ADMA) levels, and the oxidant-antioxidant balance in patients with PTE. This study was conducted as a prospective case-control study. Thirty-eight patients with PTE enrolled to the study. Age- and gender-matched 38 healthy subjects without risk factors for pulmonary embolism were selected as control group. Venous blood samples were obtained from the PTE patients during the initial diagnosis and at the first month of treatment and from the control subjects. Interleukine-6 (IL-6), tumor necrosis factor alpha (TNF-α), total antioxidant status (TAS), total oxidant status (TOS), and ADMA levels were measured for all the samples. The results of patients and healthy subjects were compared. The mean age of the control group was 51.81 ± 15.18 years, and the mean age of the patients was 52.90 ± 18.22 years (p = 0.770). Deep venous thrombosis was present in 68 % of the patients. While we found significant differences between the patient and control groups in terms of IL-6, TAS, TNF-α, ADMA and oxidative stress index (OSI) values (p = 0.001, p = 0.011, p = 0.038, p = 0.028, and p = 0.024, respectively), the TOS value was not different between the groups (p = 0.080). The ADMA, TNF-α, TAS, TOS, and OSI values of the patients during the initial diagnosis and at the first month of treatment were not different (p > 0.05). The results of this study indicate an increased inflammation, endothelial damage, and oxidative stress in PTE. No difference at the first month of therapy suggests ongoing processes. We consider that these markers may be useful in the diagnosis and follow up of PTE.
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