ArticleEuropean journal of clinical pharmacology2014
A qualitative study to explore how patients identify and assess symptoms as adverse drug reactions.
Article in European journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Patient beliefs and attitudes to taking statins: systematic review of qualitative studies.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Pooled it
- The value of patient reporting to the pharmacovigilance system: a systematic review.British journal of clinical pharmacology · 2017Pooled it
- Characterizing Gene Therapy Medicinal Products Post-Marketing Safety Reports Based on WHO Pharmacovigilance Database, VigiBase.Therapeutic innovation & regulatory science · 2025Article
- Evaluation of a self-screening tool and patient alert cards to help patients identify and manage severe adverse drug reactions.International journal of clinical pharmacy · 2025Article
- Patients' Identification, Management and Prevention of Adverse Drug Reactions: A Cross-Sectional Survey of Patients with Severe Adverse Drug Reactions.Journal of clinical medicine · 2024Article
- Accuracy in patient-reported adverse drug reactions and their recognition: a mixed-methods study.International journal of clinical pharmacy · 2024Article
- Comparing patient reported and medical record data of adverse drug reactions to anti-seizure drugs.International journal of clinical pharmacy · 2024Article
- Understanding Patient Needs Regarding Adverse Drug Reaction Reporting Smartphone Applications: A Qualitative Insight from Saudi Arabia.International journal of environmental research and public health · 2021Article
- Community Pharmacists' Views and Experiences with ADR Reporting for Complementary Medicines: A Qualitative Study in New Zealand.Drug safety · 2020Article
- Use of information sources regarding medicine side effects among the general population: a cross-sectional survey.Primary health care research & development · 2019Article
- Adverse drug event patterns experienced by patients with diabetes: A diary study in primary care.Pharmacoepidemiology and drug safety · 2019Article
- Recommendations on the Use of Mobile Applications for the Collection and Communication of Pharmaceutical Product Safety Information: Lessons from IMI WEB-RADR.Drug safety · 2019Article
- The contribution of Ghanaian patients to the reporting of adverse drug reactions: a quantitative and qualitative study.BMC public health · 2018Article
- Confidence and accuracy in identification of adverse drug reactions reported by outpatients.International journal of clinical pharmacy · 2018Article
- Interest in a Mobile App for Two-Way Risk Communication: A Survey Study Among European Healthcare Professionals and Patients.Drug safety · 2018Article
- Consumer opinions on adverse events associated with medicines and vaccines.Patient preference and adherence · 2018Article
- Evaluation of Potentially Drug-Related Patient-Reported Common Symptoms Assessed During Clinical Medication Reviews: A Cross-Sectional Observational Study.Drug safety · 2017Observational
- Factors Influencing the Use of a Mobile App for Reporting Adverse Drug Reactions and Receiving Safety Information: A Qualitative Study.Drug safety · 2017Article
- Public confidence in ADR identification and their views on ADRreporting: mixed methods study.European journal of clinical pharmacology · 2017Article
- Gender differences in statin prescription rates, adequacy of dosing, and association of statin therapy with outcome after heart failure hospitalization: a retrospective analysis in a community setting.European journal of clinical pharmacology · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo explore how Thai patients assess symptoms as adverse drug reactions (ADRs).
methodsOut-patients at two hospitals in Thailand previously reporting suspected ADRs to statins were purposively selected to cover factors relevant to the accuracy of ADR reports. Semi-structured interviews explored the mechanisms participants used to work out whether their symptoms were related to their statin. All interviews were audio-recorded, transcribed and independently thematically analyzed by two researchers.
resultsOne hundred interviews were suitable for analysis; 52 were male, age range was 36 to 77 years (mean ± S.D.: 59.83 ± 9.14) and most (92) were taking other medicines in addition to statins. Patient assessment of symptoms as ADRs fell into two major themes: medicine-related factors and external factors. Timing relationships were mentioned most frequently (74), followed by information received (55), seeing similar symptoms in others (7) and diagnosis through blood tests (4). Use of multiple medicines, consideration of the medicine versus diseases, symptoms occurring with more than one medicine or relieved through treatment reduced confidence in ADR attribution. Many participants proposed alternative explanations for symptoms, including old age. Lack of information and knowledge were obstacles to the assessment process.
conclusionsPatients assessed possible ADRs most often by considering timing relationships. While they also used medicine information, Thai patients received inadequate information to help them assess their symptoms. Patients expressed uncertainty and difficulties in deciding attribution when concomitant medicines and diseases were involved. The findings could support the development of a patient-friendly systematic tool for identifying and assessing possible ADRs.
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