ArticleDiabetologia2014
Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression.
Article in Diabetologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study.PLoS medicine · 2021Trial
- Type 1 Diabetes Mellitus and Vitamin D.International journal of molecular sciences · 2025Review
- Dietary Components in the Pathogenesis and Prevention of Type 1 Diabetes in Children.Hormone research in paediatrics · 2025Review
- Multifaceted Roles of Vitamin D for Diabetes: From Immunomodulatory Functions to Metabolic Regulations.Nutrients · 2024Review
- Differences in Plasma 25-Hydroxyvitamin D Levels at Diagnosis of Celiac Disease and Type 1 Diabetes.Nutrients · 2024Observational
- Novel Therapeutic Agents for Management of Diabetes Mellitus: A Hope for Drug Designing against Diabetes Mellitus.Life (Basel, Switzerland) · 2024Review
- Type 1 diabetes, glycemic traits, and risk of dental caries: a Mendelian randomization study.Frontiers in genetics · 2023Article
- Variants in theNutrients · 2022Article
- Editors' Commentary:International journal of spine surgery · 2022Article
- High Serum Vitamin D Concentrations, InducedFrontiers in immunology · 2022Article
- A Triple Threat? The Role of Diet, Nutrition, and the Microbiota in T1D Pathogenesis.Frontiers in nutrition · 2021Review
- Metabolomics-related nutrient patterns at seroconversion and risk of progression to type 1 diabetes.Pediatric diabetes · 2020Article
- Vitamin D deficiency 2.0: an update on the current status worldwide.European journal of clinical nutrition · 2020Review
- Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota.Frontiers in nutrition · 2020Review
- Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes.Nutrients · 2019Review
- Article
- Immunomodulatory Effect of Vitamin D and Its Potential Role in the Prevention and Treatment of Type 1 Diabetes Mellitus-A Narrative Review.Molecules (Basel, Switzerland) · 2018Review
- Associations of maternal type 1 diabetes with childhood adiposity and metabolic health in the offspring: a prospective cohort study.Diabetologia · 2018Article
- Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians.Italian journal of pediatrics · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisVitamin D deficiency is common in people with type 1 diabetes, but its role in disease progression is unclear. Our aim was to assess the prevalence of vitamin D deficiency in prediabetes (defined as the presence of multiple islet autoantibodies), and investigate whether or not progression to type 1 diabetes is faster in children with vitamin D deficiency and multiple islet autoantibodies.
methodsLevels of 25-hydroxyvitamin D [25(OH)D] were measured in 108 children with multiple islet autoantibodies within 2 years of islet autoantibody seroconversion, in 406 children who remained islet autoantibody-negative and in 244 patients with newly diagnosed type 1 diabetes. Children with multiple islet autoantibodies were prospectively followed for a median of 5.8 years (interquartile range 3.4-8.6 years) to monitor progression to type 1 diabetes.
resultsIn the cross-sectional analysis, 25(OH)D levels were lower and the prevalence of vitamin D deficiency (<50 nmol/l) was higher in children with prevalent multiple islet autoantibodies than in islet autoantibody-negative children (59.9 ± 3.0 vs 71.9 ± 1.5 nmol/l; p < 0.001; 39.8% vs 28.3%; p = 0.021). The differences in vitamin D levels between the groups were greatest in summer. The cumulative incidence of type 1 diabetes at 10 years after seroconversion was similar between children with vitamin D deficiency and those with sufficient vitamin D levels (51.8% [95% CI 29.3, 74.3] vs 55.4% [95% CI 35.5, 72.3], p = 0.8). CONCLUSIONS/
interpretationVitamin D levels were lower in children with multiple islet autoantibodies and in children with type 1 diabetes than in autoantibody-negative children. However, vitamin D deficiency was not associated with faster progression to type 1 diabetes in children with multiple islet autoantibodies.
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