ArticleEnvironmental health perspectives2014
Human health effects of tetrachloroethylene: key findings and scientific issues.
Article in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 245 citations in OpenAlex.
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- Article
- A case-control study of early-life residential exposure to tetrachloroethylene and risks of childhood cancer and birth defects.Environment international · 2025Article
- Carcinogen metabolism and bladder cancer: role of gut microbiota in disease and prevention.Frontiers in cellular and infection microbiology · 2025Review
- Tetrachloroethylene exposure and neurobehavioral performance among children living near multiple contamination sites.The Science of the total environment · 2024Article
- Parkinson's Disease Progression and Exposure to Contaminated Water at Camp Lejeune.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Occupational exposures and cancer risk in commercial laundry and dry cleaning industries: a scoping review.BMC public health · 2023Article
- Association between resilience promotion factors during childhood and risk of drug use disorder during adulthood.Addiction and substance abuse · 2023Article
- Toxicity assessments of selected trichloroethylene and perchloroethylene metabolites in three in vitro human placental models.Reproductive toxicology (Elmsford, N.Y.) · 2022Article
- A pilot study characterizing tetrachloroethylene exposure with exhaled breath in an impacted community.Environmental pollution (Barking, Essex : 1987) · 2022Article
- Risk of bladder cancer and lymphoma in dogs is associated with pollution indices by county of residence.Veterinary and comparative oncology · 2022Article
- Quantitative Characterization of Population-Wide Tissue- and Metabolite-Specific Variability in Perchloroethylene Toxicokinetics in Male Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Perchloroethylene and Dry Cleaning: It's Time to Move the Industry to Safer Alternatives.Frontiers in public health · 2021Review
- Drug use disorder following early life exposure to tetrachloroethylene (PCE)-contaminated drinking water: a retrospective cohort study.Environmental health : a global access science source · 2020Article
- PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice.Toxicology and applied pharmacology · 2020Article
- Reproductive and developmental health effects of prenatal exposure to tetrachloroethylene-contaminated drinking water.Environmental science. Processes & impacts · 2020Article
- Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice.Toxicology and applied pharmacology · 2018Article
- Role of xenobiotics in the induction and progression of fatty liver disease.Toxicology research · 2018Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe U.S. Environmental Protection Agency (EPA) completed a toxicological review of tetrachloroethylene (perchloroethylene, PCE) in February 2012 in support of the Integrated Risk Information System (IRIS).
objectivesWe reviewed key findings and scientific issues regarding the human health effects of PCE described in the U.S. EPA's Toxicological Review of Tetrachloroethylene (Perchloroethylene).
methodsThe updated assessment of PCE synthesized and characterized a substantial database of epidemiological, experimental animal, and mechanistic studies. Key scientific issues were addressed through modeling of PCE toxicokinetics, synthesis of evidence from neurological studies, and analyses of toxicokinetic, mechanistic, and other factors (tumor latency, severity, and background rate) in interpreting experimental animal cancer findings. Considerations in evaluating epidemiological studies included the quality (e.g., specificity) of the exposure assessment methods and other essential design features, and the potential for alternative explanations for observed associations (e.g., bias or confounding). DISCUSSION: Toxicokinetic modeling aided in characterizing the complex metabolism and multiple metabolites that contribute to PCE toxicity. The exposure assessment approach-a key evaluation factor for epidemiological studies of bladder cancer, non-Hodgkin lymphoma, and multiple myeloma-provided suggestive evidence of carcinogenicity. Bioassay data provided conclusive evidence of carcinogenicity in experimental animals. Neurotoxicity was identified as a sensitive noncancer health effect, occurring at low exposures: a conclusion supported by multiple studies. Evidence was integrated from human, experimental animal, and mechanistic data sets in assessing adverse health effects of PCE.
conclusionsPCE is likely to be carcinogenic to humans. Neurotoxicity is a sensitive adverse health effect of PCE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.