ArticleInternational journal of molecular sciences2014
Dominant repression by Arabidopsis transcription factor MYB44 causes oxidative damage and hypersensitivity to abiotic stress.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed.
- Comparative transcriptomic and biochemical analyses reveal candidate regulatory genes associated with early drought response signatures in contrasting rapeseed (Brassica napus) cultivars.Scientific reports · 2025Article
- Physiological and Transcriptome Analysis Reveal the Underlying Mechanism of Salicylic Acid-Alleviated Drought Stress in Kenaf (Life (Basel, Switzerland) · 2025Article
- Genome-wide association study for stalk lodging resistance related traits in maize (Zea mays L.).BMC genomics · 2024Article
- Using single-sample networks and genetic algorithms to identify radiation-responsive genes in rice affected by heavy ions of the galactic cosmic radiation with different LET values.Frontiers in plant science · 2024Article
- Genome-Wide Analysis of MYB Genes inInternational journal of molecular sciences · 2023Article
- MYB44 regulates PTI by promoting the expression of EIN2 and MPK3/6 in Arabidopsis.Plant communications · 2023Article
- PagMYB205 Negatively Affects Poplar Salt Tolerance through Reactive Oxygen Species Scavenging and Root Vitality Modulation.International journal of molecular sciences · 2023Article
- Phloem-MobilePlants (Basel, Switzerland) · 2023Article
- The transcription factor CmERFI-2 represses CmMYB44 expression to increase sucrose levels in oriental melon fruit.Plant physiology · 2023Article
- Tree peony PsMYB44 negatively regulates petal blotch distribution by inhibiting dihydroflavonol-4-reductase gene expression.Annals of botany · 2023Article
- MYB44-ENAP1/2 restricts HDT4 to regulate drought tolerance in Arabidopsis.PLoS genetics · 2022Article
- VaMYB44 transcription factor from Chinese wild Vitis amurensis negatively regulates cold tolerance in transgenic Arabidopsis thaliana and V. vinifera.Plant cell reports · 2022Article
- Regulatory network established by transcription factors transmits drought stress signals in plant.Stress biology · 2022Review
- Identification of differentially expressed genes in salt-tolerant oilseed sunflower (Helianthus annuus L.) genotype by RNA sequencing.Molecular biology reports · 2022Article
- Comparative transcriptome analysis unveiling reactive oxygen species scavenging system ofFrontiers in plant science · 2022Article
- Dynamic transcriptome analysis suggests the key genes regulating seed development and filling in Tartary buckwheat (Frontiers in genetics · 2022Article
- Characterization of the gene expression profile response to drought stress inFrontiers in plant science · 2022Article
- Transcriptome analysis of Rafflesia cantleyi flower stages reveals insights into the regulation of senescence.Scientific reports · 2021Article
- Article
- Role of Reactive Oxygen Species and Hormones in Plant Responses to Temperature Changes.International journal of molecular sciences · 2021Review
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2 authors.
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Abstract
In any living species, stress adaptation is closely linked with major changes of the gene expression profile. As a substrate protein of the rapidly stress-induced mitogen-activated protein kinase MPK3, Arabidopsis transcription factor MYB44 likely acts at the front line of stress-induced re-programming. We recently characterized MYB44 as phosphorylation-dependent positive regulator of salt stress signaling. Molecular events downstream of MYB44 are largely unknown. Although MYB44 binds to the MBSII element in vitro, it has no discernible effect on MBSII-driven reporter gene expression in plant co-transfection assays. This may suggest limited abundance of a synergistic co-regulator. MYB44 carries a putative transcriptional repression (Ethylene responsive element binding factor-associated Amphiphilic Repression, EAR) motif. We employed a dominant repressor strategy to gain insights into MYB44-conferred stress resistance. Overexpression of a MYB44-REP fusion markedly compromised salt and drought stress tolerance--the opposite was seen in MYB44 overexpression lines. MYB44-mediated resistance likely results from induction of tolerance-enhancing, rather than from repression of tolerance-diminishing factors. Salt stress-induced accumulation of destructive reactive oxygen species is efficiently prevented in transgenic MYB44, but accelerated in MYB44-REP lines. Furthermore, heterologous overexpression of MYB44-REP caused tissue collapse in Nicotiana. A mechanistic model of MAPK-MYB-mediated enhancement in the antioxidative capacity and stress tolerance is proposed. Genetic engineering of MYB44 variants with higher trans-activating capacity may be a means to further raise stress resistance in crops.
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