ArticleEnvironmental health perspectives2014
Association of long-term exposure to traffic-related air pollution with blood pressure and hypertension in an adult population-based cohort in Spain (the REGICOR study).
Article in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Systematic review and meta-analysis of cohort studies of long term outdoor nitrogen dioxide exposure and mortality.PloS one · 2021Pooled it
- Chronic mercury exposure and blood pressure in children and adolescents: a systematic review.Environmental science and pollution research international · 2019Pooled it
- WHO Environmental Noise Guidelines for the European Region: A Systematic Review on Environmental Noise and Cardiovascular and Metabolic Effects: A Summary.International journal of environmental research and public health · 2018Pooled it
- Pooled it
- Randomized Cross-Over Study of In-Vehicle Cabin Air Filtration, Air Pollution Exposure, and Acute Changes to Heart Rate Variability, Saliva Cortisol, and Cognitive Function.Environmental science & technology · 2023Trial
- Long-Term Exposure to Ambient Air Pollution and Metabolic Syndrome and Its Components.Journal of obesity & metabolic syndrome · 2025Review
- Global Public Health Implications of Traffic Related Air Pollution: Systematic Review.Environmental health insights · 2024Article
- Ozone Exposure During Pregnancy and Risk of Gestational Hypertension or Preeclampsia in China.JAMA network open · 2023Article
- Long-Term Exposures to Urban Noise and Blood Pressure Levels and Control Among Older Adults.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Long-term exposure to high particulate matter pollution and incident hypertension: a 12-year cohort study in northern China.Journal of human hypertension · 2021Article
- Benefits of active commuting on cardiovascular health modified by ambient fine particulate matter in China: A prospective cohort study.Ecotoxicology and environmental safety · 2021Article
- Association between long term exposure to particulate matter and incident hypertension in Spain.Scientific reports · 2021Article
- Road traffic noise and cardiovascular disease risk factors in UK Biobank.European heart journal · 2021Article
- Air pollution, noise exposure, and metabolic syndrome - A cohort study in elderly Mexican-Americans in Sacramento area.Environment international · 2020Article
- Residential Proximity to Major Roadways and Prevalent Hypertension Among Older Women and Men: Results From the Chinese Longitudinal Healthy Longevity Survey.Frontiers in cardiovascular medicine · 2020Article
- Synthesis of Harvard Environmental Protection Agency (EPA) Center studies on traffic-related particulate pollution and cardiovascular outcomes in the Greater Boston Area.Journal of the Air & Waste Management Association (1995) · 2019Article
- Bibliometric analysis of cardiometabolic disorders studies involving NOBMC public health · 2019Article
- Short-term effects of ambient air pollution and cardiovascular events in Shiraz, Iran, 2009 to 2015.Environmental science and pollution research international · 2019Article
- Longitudinal Analysis of Long-Term Air Pollution Levels and Blood Pressure: A Cautionary Tale from the Multi-Ethnic Study of Atherosclerosis.Environmental health perspectives · 2018Article
- Associations of long-term fine particulate matter exposure with prevalent hypertension and increased blood pressure in older Americans.Environmental research · 2018Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term exposure to traffic-related air pollution may increase blood pressure (BP) and induce hypertension. However, evidence supporting these associations is limited, and they may be confounded by exposure to traffic noise and biased due to inappropriate control for use of BP-lowering medications.
objectivesWe evaluated the associations of long-term traffic-related air pollution with BP and prevalent hypertension, adjusting for transportation noise and assessing different methodologies to control for BP-lowering medications.
methodsWe measured systolic (SBP) and diastolic BP (DBP) at baseline (years 2003-2005) in 3,700 participants, 35-83 years of age, from a population-based cohort in Spain. We estimated home outdoor annual average concentrations of nitrogen dioxide (NO2) with a land-use regression model. We used multivariate linear and logistic regression.
resultsA 10-μg/m3 increase in NO2 levels was associated with 1.34 mmHg (95% CI: 0.14, 2.55) higher SBP in nonmedicated individuals, after adjusting for transportation noise. Results were similar in the entire population after adjusting for medication, as commonly done, but weaker when other methods were used to account for medication use. For example, when 10 mmHg were added to the measured SBP levels of medicated participants, the association was β = 0.78 (95% CI: -0.43, 2.00). NO2 was not associated with hypertension. Associations of NO2 with SBP and DBP were stronger in participants with cardiovascular disease, and the association with SBP was stronger in those exposed to high traffic density and traffic noise levels ≥ 55 dB(A).
conclusionsWe observed a positive association between long-term exposure to NO2 and SBP, after adjustment for transportation noise, which was sensitive to the methodology used to account for medication.
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