ArticleMicrobiology (Reading, England)2014
Vibrio cholerae NspS, a homologue of ABC-type periplasmic solute binding proteins, facilitates transduction of polyamine signals independent of their transport.
Article in Microbiology (Reading, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Two-component systems in Vibrio species: Regulation of virulence and implications for therapeutic development.Folia microbiologica · 2026Review
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- Functional analysis of cyclic diguanylate-modulating proteins inbioRxiv : the preprint server for biology · 2024Article
- Control of biofilm formation by anProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Control of Biofilm Formation by anbioRxiv : the preprint server for biology · 2023Article
- TheMicrobiology (Reading, England) · 2023Article
- Quantitative input-output dynamics of a c-di-GMP signal transduction cascade in Vibrio cholerae.PLoS biology · 2022Article
- The citrus plant pathogenBiochemistry and biophysics reports · 2021Article
- Article
- Inverse regulation ofeLife · 2021Article
- A mutagenic screen reveals NspS residues important for regulation ofMicrobiology (Reading, England) · 2021Article
- Biofilms by bacterial human pathogens: Clinical relevance - development, composition and regulation - therapeutical strategies.Microbial cell (Graz, Austria) · 2021Review
- The role of solute binding proteins in signal transduction.Computational and structural biotechnology journal · 2021Review
- Iron is not everything: unexpected complex metabolic responses between iron-cycling microorganisms.The ISME journal · 2020Article
- Silence is golden: gene silencing of V. cholerae during intestinal colonization delivers new aspects to the acid tolerance response.Gut microbes · 2019Article
- Structure and function of a novel periplasmic chitooligosaccharide-binding protein from marineThe Journal of biological chemistry · 2018Article
- Spermine inhibitsThe Journal of biological chemistry · 2017Article
- The ins and outs of cyclic di-GMP signaling in Vibrio cholerae.Current opinion in microbiology · 2017Review
- Relative contributions of norspermidine synthesis and signaling pathways to the regulation of Vibrio cholerae biofilm formation.PloS one · 2017Article
- Spermidine Inversely Influences Surface Interactions and Planktonic Growth in Agrobacterium tumefaciens.Journal of bacteriology · 2016Article
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Authors and funding
9 authors at 8 institutions in 1 country.
Funding
Abstract
The polyamines norspermidine and spermidine are among the environmental signals that regulate Vibrio cholerae biofilm formation. The effects of these polyamines are mediated by NspS, a member of the bacterial periplasmic solute binding protein superfamily. Almost all members of this superfamily characterized to date are components of ATP-binding cassette-type transporters involved in nutrient uptake. Consequently, in the current annotation of the V. cholerae genome, NspS has been assigned a function in transport. The objective of this study was to further characterize NspS and investigate its potential role in transport. Our results support a role for NspS in signal transduction in response to norspermidine and spermidine, but not their transport. In addition, we provide evidence that these polyamine signals are processed by c-di-GMP signalling networks in the cell. Furthermore, we present comparative genomics analyses which reveal the presence of NspS-like proteins in a variety of bacteria, suggesting that periplasmic ligand binding proteins may be widely utilized for sensory transduction.
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