ReviewJournal of the American College of Cardiology2014
Lone atrial fibrillation: does it exist?
Review in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed, 206 citations in OpenAlex.
- Clinical utility of the 4S-AF scheme in predicting progression of atrial fibrillation: data from the RACE V study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Trial
- Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation.Circulation. Cardiovascular genetics · 2015Trial
- Atrial Cardiomyopathy: Pathophysiology, Diagnostic Approaches, and Prognostic Implications-A Narrative Review.Journal of clinical medicine · 2026Review
- Detection of exercising ectopic atrial and ventricular beats using non-linear analysis of clinically normal racehorse electrocardiograms at rest or low-intensity exercise.Scientific reports · 2026Article
- Systems-Level in Silico Bioinformatic Profiling Identifies Key Hub Genes and Potential Therapeutic Targets in Atrial Fibrillation without Overt Comorbidity.Research in heart yield and translational medicine · 2026Article
- Brazilian Atrial Fibrillation Guidelines - 2025.Arquivos brasileiros de cardiologia · 2025Article
- The Impact of Comorbidities on Pulmonary Function Measured by Spirometry in Patients After Percutaneous Cryoballoon Pulmonary Vein Isolation Due to Atrial Fibrillation.Journal of clinical medicine · 2025Article
- Association Between Age at Diagnosis of Atrial Fibrillation and Subsequent Risk of Ischemic Stroke.Journal of the American Heart Association · 2025Article
- Echocardiographic Findings in Jordanian Atrial Fibrillation Patients: Analysis from Jo-Fib Study.Medicina (Kaunas, Lithuania) · 2025Article
- Tilt-induced changes in f-wave characteristics during atrial fibrillation: an experimental and computational investigation.Frontiers in physiology · 2025Article
- Article
- Cardiomyocyte and endothelial cells play distinct roles in the tumour necrosis factor (TNF)-dependent atrial responses and increased atrial fibrillation vulnerability induced by endurance exercise training in mice.Cardiovascular research · 2023Article
- Low plasma renin activity is associated with "Apparently" idiopathic atrial fibrillation.International journal of cardiology. Heart & vasculature · 2023Article
- Genetic Basis of Early Onset Atrial Fibrillation in Patients without Risk Factors.Journal of cardiovascular development and disease · 2023Article
- The effectiveness of atrial fibrillation special clinic on oral anticoagulant use for high risk atrial fibrillation patients managed in the community.BMC primary care · 2023Article
- The frequency of atrial fibrillatory waves is modulated by the spatiotemporal pattern of acetylcholine release: a 3D computational study.Frontiers in physiology · 2023Article
- Review
- Outcome of life-threatening arrhythmias among patients presenting in an emergency setting at a tertiary hospital in Accra-Ghana.BMC cardiovascular disorders · 2022Article
- COVID-19 increases the risk for the onset of atrial fibrillation in hospitalized patients.Scientific reports · 2022Article
- Plasma growth differentiation factor-15 in patients with "lone" atrial fibrillation.Journal of clinical laboratory analysis · 2022Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 4 countries.
Funding
Abstract
The historical origin of the term "lone atrial fibrillation" (AF) predates by 60 years our current understanding of the pathophysiology of AF, the multitude of known etiologies for AF, and our ability to image and diagnose heart disease. The term was meant to indicate AF in patients for whom subsequent investigations could not demonstrate heart disease, but for many practitioners has become synonymous with "idiopathic AF." As the list of heart diseases has expanded and diagnostic techniques have improved, the prevalence of lone AF has fallen. The legacy of the intervening years is that definitions of lone AF in the literature are inconsistent so that studies of lone AF are not comparable. Guidelines provide a vague definition of lone AF but do not provide direction about how much or what kind of imaging and other testing are necessary to exclude heart disease. There has been an explosion in the understanding of the pathophysiology of AF in the last 20 years in particular. Nevertheless, there are no apparently unique mechanisms for AF in patients categorized as having lone AF. In addition, the term "lone AF" is not invariably useful in making treatment decisions, and other tools for doing so have been more thoroughly and carefully validated. It is, therefore, recommended that use of the term "lone AF" be avoided.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.