ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2014
Risk of esophageal adenocarcinoma decreases with height, based on consortium analysis and confirmed by Mendelian randomization.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Mapping research trends in esophageal cancer immunotherapy: A decade of thematic evolution and emerging priorities.Human vaccines & immunotherapeutics · 2026Article
- Causal effects of genetic birth weight and gestational age on adult esophageal diseases: Mendelian randomization study.World journal of gastrointestinal oncology · 2024Article
- Epigenomics and genotype-phenotype association analyses reveal conserved genetic architecture of complex traits in cattle and human.BMC biology · 2020Article
- Adult height, body mass index change, and body shape change in relation to esophageal squamous cell carcinoma risk: A population-based case-control study in China.Cancer medicine · 2019Article
- Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Adult height and risk of 50 diseases: a combined epidemiological and genetic analysis.BMC medicine · 2018Article
- Mendelian randomization studies of cancer risk: a literature review.Current epidemiology reports · 2018Article
- A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk.Scientific reports · 2017Article
- Premature Birth and Large for Gestational Age Are Associated with Risk of Barrett's Esophagus in Adults.Digestive diseases and sciences · 2016Article
- Adult height, nutrition, and population health.Nutrition reviews · 2016Review
- Risk Profiles for Barrett's Esophagus Differ between New and Prevalent, and Long- and Short-Segment Cases.PloS one · 2016Article
- General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition.International journal of cancer · 2015Article
- Epidemiology, Diagnosis, and Management of Esophageal Adenocarcinoma.Gastroenterology · 2015Review
- A review of the epidemiology of Barrett's oesophagus and oesophageal adenocarcinoma.Best practice & research. Clinical gastroenterology · 2015Review
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19 authors at 15 institutions in 5 countries.
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Abstract
BACKGROUND &
aimsRisks for some cancers increase with height. We investigated the relationship between height and risk of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE).
methodsWe analyzed epidemiologic and genome-wide genomic data from individuals of European ancestry in the Barrett's and Esophageal Adenocarcinoma Consortium, from 999 cases of EAC, 2061 cases of BE, and 2168 population controls. Multivariable logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for associations between height and risks of EAC and BE. We performed a Mendelian randomization analysis to estimate an unconfounded effect of height on EAC and BE using a genetic risk score derived from 243 genetic variants associated with height as an instrumental variable.
resultsHeight was associated inversely with EAC (per 10-cm increase in height: OR, 0.70; 95% CI, 0.62-0.79 for men and OR, 0.57; 95% CI 0.40-0.80 for women) and BE (per 10-cm increase in height: OR, 0.69; 95% CI, 0.62-0.77 for men and OR, 0.61; 95% CI, 0.48-0.77 for women). The risk estimates were consistent across strata of age, education level, smoking, gastroesophageal reflux symptoms, body mass index, and weight. Mendelian randomization analysis yielded results quantitatively similar to those from the conventional epidemiologic analysis.
conclusionsHeight is associated inversely with risks of EAC and BE. Results from the Mendelian randomization study showed that the inverse association observed did not result from confounding factors. Mechanistic studies of the effect of height on EAC and BE are warranted; height could have utility in clinical risk stratification.
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