Evidence map›Paper›PMID 24530563›Full record

ArticleGynecologic oncology2014

Intrauterine factors and risk of nonepithelial ovarian cancers.

Weiva Sieh, Kristina Sundquist, Jan Sundquist, Marilyn A Winkleby, Casey Crump

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Weiva SiehDepartment of Health Research and Policy, Stanford University, Stanford, CA, USA. Electronic address: wsieh@stanford.edu.
Kristina SundquistCenter for Primary Health Care Research, Lund University, Malmö, Sweden; Stanford Prevention Research Center, Stanford University, Stanford, CA, USA.
Jan SundquistCenter for Primary Health Care Research, Lund University, Malmö, Sweden; Stanford Prevention Research Center, Stanford University, Stanford, CA, USA.
Marilyn A WinklebyStanford Prevention Research Center, Stanford University, Stanford, CA, USA.
Casey CrumpDepartment of Medicine, Stanford University, Stanford, CA, USA.
Stanford University · US

Funding

Mothers, Places, and Preterm BirthR01HD052848 · NICHD · LUNDS UNIVERSITET · PI SUNDQUIST, JAN O · 2007 to 2010
$1.8M
Genetic Epidemiology of Ovarian and Prostate CancerK07CA143047 · NCI · STANFORD UNIVERSITY · PI SIEH, WEIVA · 2010 to 2014
$867k
Perinatal, Familial, and Neighborhood Risk Factors for Childhood CancerR03CA171017 · NCI · LUNDS UNIVERSITET · PI CRUMP, CASEY · 2013 to 2014
$98k
NCI NIH HHS K07 CA143047NCI NIH HHS K07CA143047NCI NIH HHS R03 CA171017NCI NIH HHS R03CA171017NICHD NIH HHS R01 HD052848NICHD NIH HHS R01HD052848
6 · The paper itself

Abstract

objectiveThe majority of ovarian tumors in girls and young women are nonepithelial in origin. The etiology of nonepithelial ovarian tumors remains largely unknown, and intrauterine exposures may play an important role. We examined the association of perinatal factors with risk of nonepithelial ovarian tumors in girls and young women.

methodsNational cohort study of 1,536,057 women born in Sweden during 1973-2004 and followed for diagnoses of nonepithelial ovarian tumors through 2009 (attained ages 5-37 years). Perinatal and maternal characteristics and cancer diagnoses were ascertained using nationwide health registry data.

results147 women were diagnosed with nonepithelial ovarian tumors in 31.6 million person-years of follow-up, including 94 with germ cell tumors and 53 with sex-cord stromal tumors. Women born preterm (<37 weeks of gestation) had a significantly increased risk of developing nonepithelial ovarian tumors (adjusted hazard ratio 1.86, 95% CI 1.03-3.37; p=0.04). Histological subgroup analyses showed that preterm birth was associated with increased risk of sex-cord stromal tumors (4.39, 2.12-9.10; p<0.001), but not germ cell tumors (0.68, 0.21-2.15; p=0.51). No significant associations were found with fetal growth, birth order, and maternal age at birth.

conclusionsThis large cohort study provides the first evidence that preterm birth is a risk factor for developing sex cord-stromal tumors. Ovarian hyperstimulation in response to high gonadotropin levels in preterm girls could mediate disease risk through the proliferative and steroidogenic effects of FSH and LH on granulosa and theca cells, from which most sex-cord stromal tumors are derived.

Indexed as

Gestational AgeAdolescentAdultChildChild, PreschoolCohort StudiesFemaleHumansInfant, NewbornInfant, PrematureNeoplasms, Germ Cell and EmbryonalOvarian NeoplasmsPregnancyPrenatal Exposure Delayed EffectsProportional Hazards ModelsRisk FactorsGerm cell tumorsGestational ageNonepithelial ovarian cancersPerinatal factorsPreterm birthSex-cord stromal tumors

Identifiers

PMID24530563
PMCPMC4006291
OpenAlexW1983952643

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.