ArticleNeuroscience2014
Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlative responses of lumbar dorsal horn neurons in the mouse.
Article in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Kappa opioid receptors in excitatory spinal neurons gate acute pain: evidence from mouse and human.bioRxiv : the preprint server for biology · 2026Article
- Neuroimmune interplay during type 2 inflammation: Symptoms, mechanisms, and therapeutic targets in atopic diseases.The Journal of allergy and clinical immunology · 2024Review
- A tactile twist: decoding the phenomena of mechanical itch and alloknesis.Frontiers in molecular neuroscience · 2023Review
- Differential Diagnosis and Treatment of Itching in Children and Adolescents.Biomedicines · 2021Review
- Intractable Itch in Atopic Dermatitis: Causes and Treatments.Biomedicines · 2021Review
- The Neurokinin-1 Receptor is Expressed with Gastrin-Releasing Peptide Receptor in Spinal Interneurons and Modulates Itch.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Ablation of spinal cord estrogen receptor α-expressing interneurons reduces chemically induced modalities of pain and itch.The Journal of comparative neurology · 2020Article
- Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors.Nature communications · 2020Article
- FK506 (tacrolimus) causes pain sensation through the activation of transient receptor potential ankyrin 1 (TRPA1) channels.The journal of physiological sciences : JPS · 2019Article
- Facilitation of MrgprD by TRP-A1 promotes neuropathic pain.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Cooling Relief of Acute and Chronic Itch Requires TRPM8 Channels and Neurons.The Journal of investigative dermatology · 2018Article
- Innocuous warming enhances peripheral serotonergic itch signaling and evokes enhanced responses in serotonin-responsive dorsal horn neurons in the mouse.Journal of neurophysiology · 2017Article
- Spinal neurons that contain gastrin-releasing peptide seldom express Fos or phosphorylate extracellular signal-regulated kinases in response to intradermal chloroquine.Molecular pain · 2016Article
- Intradermal endothelin-1 excites bombesin-responsive superficial dorsal horn neurons in the mouse.Journal of neurophysiology · 2015Article
- A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch.Pain · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have further developed a behavioral model of itch and pain in the lower hindlimb (calf) originally reported by LaMotte et al. (2011) that allows comparisons with responses of lumbar dorsal horn neurons to pruritic and noxious stimuli. Intradermal (id) microinjection of the pruritogens histamine, SLIGRL-NH2 (agonist of PAR-2 and MrgprC11) and chloroquine (agonist of MrgprA3) into the calf of the lower limb elicited significant biting and a small amount of licking directed to the injection site, over a 30-min time course. Following id injection of histamine, low-threshold mechanical stimuli reliably elicited discrete episodes of biting (alloknesis) over a longer time course; significantly less alloknesis was observed following id injection of SLIGRL-NH2. Capsaicin injections elicited licking but little biting. Following id injection of capsaicin, low-threshold mechanical stimuli elicited discrete hindlimb flinches (allodynia) over a prolonged (>2h) time course. In single-unit recordings from superficial lumbar dorsal horn neurons, low-threshold mechanically evoked responses were significantly enhanced, accompanied by receptive field expansion, following id injection of histamine in histamine-responsive neurons. This was not observed in histamine-insensitive neurons, or following id injection of saline or SLIGRL-NH2, regardless of whether the latter activated the neuron or not. These results suggest that itch-responsive neurons are selectively sensitized by histamine but not SLIGRL-NH2 to account for alloknesis. The presently described "calf" model appears to distinguish between itch- and pain-related behavioral responses, and provides a basis to investigate lumbar spinal neural mechanisms underlying itch, alloknesis, pain and allodynia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.