Evidence map›Paper›PMID 24530186›Full record

ReviewThe Science of the total environment2014

Modulation of persistent organic pollutant toxicity through nutritional intervention: emerging opportunities in biomedicine and environmental remediation.

Michael C Petriello, Bradley J Newsome, Thomas D Dziubla, J Zach Hilt, Dibakar Bhattacharyya, Bernhard Hennig

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Science of the total environment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michael C PetrielloSuperfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
Bradley J NewsomeSuperfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Chemistry, College of Arts and Sciences, University of Kentucky, Lexington, KY 40506, USA.
Thomas D DziublaSuperfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, Lexington, KY 40506, USA.
J Zach HiltSuperfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, Lexington, KY 40506, USA.
Dibakar BhattacharyyaSuperfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, Lexington, KY 40506, USA.
Bernhard HennigSuperfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA; Department of Animal and Food Sciences, College of Agriculture Food and Environment, University of Kentucky, Lexington, KY 40546, USA.
University of Kentucky · USThe Graduate Center, CUNY · US

Funding

Vascular Mechanisms of PCB-Induced Brain MetastasesP42ES007380 · NIEHS · UNIVERSITY OF KENTUCKY · PI PENNELL, KELLY G · 1997 to 2024
$47.8M
NIEHS NIH HHS P42 ES007380NIEHS NIH HHS P42ES007380
6 · The paper itself

Abstract

Environmental pollution is increasing worldwide, and there is evidence that exposure to halogenated persistent organic pollutants (POPs) such as polychlorinated biphenyls can contribute to the pathology of inflammatory diseases such as atherosclerosis, diabetes, and cancer. Pollutant removal from contaminated sites and subsequent pollutant degradation are critical for reducing the long-term health risks associated with exposure. However, complete remediation of a toxicant from the environment is very difficult and cost-prohibitive. Furthermore, remediation technologies often result in the generation of secondary toxicants. Considering these circumstances, environmentally-friendly and sustainable remediation technologies and biomedical solutions to reduce vulnerability to environmental chemical insults need to be explored to reduce the overall health risks associated with exposure to environmental pollutants. We propose that positive lifestyle changes such as healthful nutrition and consumption of diets rich in fruits and vegetables or bioactive nutrients with antioxidant and/or anti-inflammatory properties will reduce the body's vulnerability to environmental stressors and thus reduce toxicant-mediated disease pathologies. Interestingly, emerging evidence now implicates the incorporation of bioactive nutrients, such as plant-derived polyphenols, in technologies focused on the capture, sensing and remediation of halogenated POPs. We propose that human nutritional intervention in concert with the use of natural polyphenol sensing and remediation platforms may provide a sensible means to develop primary and long-term prevention strategies of diseases associated with many environmental toxic insults including halogenated POPs.

Indexed as

AntioxidantsEnvironmental PollutantsEnvironmental PollutionEnvironmental Restoration and RemediationFoodHumansNutritive ValueAntioxidantsEnvironmental PollutantsAntioxidant responseNutritionOxidative stressPolyphenolPOP toxicitySustainable remediation

Identifiers

PMID24530186
PMCPMC4077968
OpenAlexW1974328633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.