ArticleNeuron2014
Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development.Molecular psychiatry · 2016Pooled it
- The effect of fampridine on working memory: a randomized controlled trial based on a genome-guided repurposing approach.Molecular psychiatry · 2025Trial
- CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial.Scientific reports · 2017Trial
- Orthogonal-Rotational Dynamics Supports Efficient Encoding and Updating for Streaming Information in Working Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Evaluating in-vivo spontaneous firing rate in the brain based on neuronal noise modeling.Communications biology · 2025Article
- Druggable Targets for Postpartum Depression: A Mendelian Randomization and Colocalization Study.Cellular and molecular neurobiology · 2025Article
- Integrating Neuroimaging and Genetics via Contrastive Learning for Working Memory.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2024Article
- Sex-dependent differences in connectivity patterns are related to episodic memory recall.Human brain mapping · 2023Article
- Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture.Research square · 2023Article
- Article
- Neurofunctional underpinnings of individual differences in visual episodic memory performance.Nature communications · 2023Article
- Human cerebellum and corticocerebellar connections involved in emotional memory enhancement.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Imbalance Between Prefronto-Thalamic and Sensorimotor-Thalamic Circuitries Associated with Working Memory Deficit in Schizophrenia.Schizophrenia bulletin · 2022Article
- The morphometry of left cuneus mediating the genetic regulation on working memory.Human brain mapping · 2021Article
- A psychiatric disease-related circular RNA controls synaptic gene expression and cognition.Molecular psychiatry · 2020Article
- CHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research.Molecular psychiatry · 2020Review
- Visual Exploration at Higher Fixation Frequency Increases Subsequent Memory Recall.Cerebral cortex communications · 2020Article
- Genetic Variation in the Psychiatric Risk Gene CACNA1C Modulates Reversal Learning Across Species.Schizophrenia bulletin · 2019Article
- Multiple genetic loci affect place learning and memory performance in Drosophila melanogaster.Genes, brain, and behavior · 2019Article
- Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders.International journal of molecular sciences · 2019Review
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Authors and funding
22 authors at 10 institutions in 3 countries.
Funding
Abstract
Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is a heritable trait. Working memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets of young and aged cognitively healthy subjects (n = 2,824) and in a large schizophrenia case-control sample (n = 32,143). The voltage-gated cation channel activity gene set, consisting of genes related to neuronal excitability, was robustly linked to performance in working memory-related tasks across ages and to schizophrenia. Functional brain imaging in 707 healthy participants linked this gene set also to working memory-related activity in the parietal cortex and the cerebellum. Gene set analyses may help to dissect the molecular underpinnings of cognitive dimensions, brain activity, and psychopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.