Evidence map›Paper›PMID 24529725›Full record

ReviewInternational review of cell and molecular biology2014

New insights into the role of Plg-RKT in macrophage recruitment.

Lindsey A Miles, Shahrzad Lighvani, Nagyung Baik, Caitlin M Parmer, Sophia Khaldoyanidi, Barbara M Mueller, Robert J Parmer

Open access · greenAbstract readReview
In one paragraph

Review in International review of cell and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 37 citations in OpenAlex.

  1. Journal of inflammation research · 2025
    Article
  2. Review
  3. Article
  4. A Peculiar Disease in a Young Woman Wanting to Get PregnantTurkish journal of haematology : official journal of Turkish Society of Haematology · 2021
    Article
  5. Review
  6. Review
  7. Review
  8. Plasminogen Receptors and Fibrinolysis.International journal of molecular sciences · 2021
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Functions of the plasminogen receptor Plg-RJournal of thrombosis and haemostasis : JTH · 2020
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Lindsey A MilesDepartment of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA. Electronic address: lmiles@scripps.edu.
Shahrzad LighvaniDepartment of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
Nagyung BaikDepartment of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
Caitlin M ParmerDepartment of Cell, Molecular and Developmental Biology, Yale University, New Haven, Connecticut, USA.
Sophia KhaldoyanidiTorrey Pines Institute for Molecular Studies, San Diego, California, USA.
Barbara M MuellerTorrey Pines Institute for Molecular Studies, San Diego, California, USA.
Robert J ParmerDepartment of Medicine, University of California San Diego, La Jolla, California, USA; Department of Medicine, Veterans Administration San Diego Healthcare System, San Diego, California, USA.
Scripps Research Institute · USTorrey Pines Institute For Molecular Studies · USVA San Diego Healthcare System · USYale University · US

Funding

Regulation of plasminogen-dependent cell functions by the novel receptor, Plg-RKTR01HL081046 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI MILES, LINDSEY A · 2007 to 2024
$8.7M
BLOOD SYSTEMS IN COAGULATION AND VESSEL DISEASET32HL007195 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUF, WOLFRAM · 1985 to 2011
$5.1M
A Novel Plasminogen Receptor in Breast CancerR01CA166473 · NCI · TORREY PINES INST FOR MOLECULAR STUDIES · PI MILES, LINDSEY A, MUELLER, BARBARA MARIA · 2012 to 2016
$2.1M
REGULATION OF FIBRINOLYSIS BY CELL SURFACESR01HL038272 · NHLBI · SCRIPPS RESEARCH INSTITUTE · PI MILES, LINDSEY A · 1994 to 2002
$961k
PROCESSING OF CHROMOGRANIN A BY THE FIBRINOLYTIC SYSTEMR01HL050398 · NHLBI · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI PARMER, ROBERT J · 1994 to 2001
$424k
REGULATION OF FIBRINOLYSIS BY CELL SURFACESR29HL038272 · NHLBI · SCRIPPS RESEARCH INSTITUTE · PI MILES, LINDSEY A · 1988 to 1992
–
Cell Surface Plasminogen Activation and HypertensionI01BX002026 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI PARMER, ROBERT J · 2013 to 2016
–
BLRD VA I01 BX002026NCI NIH HHS CA166473NCI NIH HHS R01 CA166473NHLBI NIH HHS HL081046NHLBI NIH HHS HL38272NHLBI NIH HHS HL50398NHLBI NIH HHS R01 HL038272NHLBI NIH HHS R01 HL050398NHLBI NIH HHS R01 HL081046NHLBI NIH HHS T32 HL007195PHS HHS H45934
6 · The paper itself

Abstract

Plasminogen (PLG) is the zymogen of plasmin, the major enzyme that degrades fibrin clots. In addition to its binding and activation on fibrin clots, PLG also specifically interacts with cell surfaces where it is more efficiently activated by PLG activators, compared with the reaction in solution. This results in association of the broad-spectrum proteolytic activity of plasmin with cell surfaces that functions to promote cell migration. Here, we review emerging data establishing a role for PLG, plasminogen receptors and the newly discovered plasminogen receptor, Plg-RKT, in macrophage recruitment in the inflammatory response, and we address mechanisms by which the interplay between PLG and its receptors regulates inflammation.

Indexed as

Amino Acid SequenceAnimalsHumansMacrophagesMolecular Sequence DataPeritonitisPlasminogenProteomicsReceptors, Cell SurfacePlasminogenReceptors, Cell SurfaceMacrophagesMonocytesPlasminogenPlasminogen receptorsPlg-R(KT)ThioglycollateTissue plasminogen activatorUrokinase

Identifiers

PMID24529725
PMCPMC4060795
OpenAlexW762758931

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.