Evidence map›Paper›PMID 24529721›Full record

ReviewInternational review of cell and molecular biology2014

Mouse primordial germ cells: a reappraisal.

Maria M Mikedis, Karen M Downs

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International review of cell and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Histogenesis of intracranial germ cell tumors: primordial germ cell vs. embryonic stem cell.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Review
  3. The mouse allantois: new insights at the embryonic-extraembryonic interface.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  4. To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm.International journal of molecular sciences · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. PRDM1/BLIMP1 is widely distributed to the nascent fetal-placental interface in the mouse gastrula.Developmental dynamics : an official publication of the American Association of Anatomists · 2017
    Article
  10. Germline development in amniotes: A paradigm shift in primordial germ cell specification.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria M MikedisDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Karen M DownsDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA. Electronic address: kdowns@wisc.edu.
University of Wisconsin–Madison · US

Funding

Morphogenesis of the chorio-allantoic placenta II: The Allantoic Core DomainR01HD042706 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI DOWNS, KAREN M · 2002 to 2012
$3.0M
NICHD NIH HHS R01 HD042706
6 · The paper itself

Abstract

Current dogma is that mouse primordial germ cells (PGCs) segregate within the allantois, or source of the umbilical cord, and translocate to the gonads, differentiating there into sperm and eggs. In light of emerging data on the posterior embryonic-extraembryonic interface, and the poorly studied but vital fetal-umbilical connection, we have reviewed the past century of experiments on mammalian PGCs and their relation to the allantois. We demonstrate that, despite best efforts and valuable data on the pluripotent state, what is and is not a PGC in vivo is obscure. Furthermore, sufficient experimental evidence has yet to be provided either for an extragonadal origin of mammalian PGCs or for their segregation within the posterior region. Rather, most evidence points to an alternative hypothesis that PGCs in the mouse allantois are part of a stem/progenitor cell pool that exhibits all known PGC "markers" and that builds/reinforces the fetal-umbilical interface, common to amniotes. We conclude by suggesting experiments to distinguish the mammalian germ line from the soma.

Indexed as

AllantoisAnimalsEmbryo, MammalianGerm CellsMammalsMiceModels, BiologicalAlkaline phosphataseAllantoic Core DomainAllantoisEmbryonic–extraembryonic interfacePRDM1Primitive streakPrimordial germ cellsSTELLA

Identifiers

PMID24529721
PMCPMC12592984
OpenAlexW104154124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.