Evidence map›Paper›PMID 24529685›Full record

SynthesisThe Journal of allergy and clinical immunology2014

Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children.

Agnes M M Sonnenschein-van der Voort, Lidia R Arends, Johan C de Jongste, Isabella Annesi-Maesano, S Hasan Arshad, Henrique Barros, Mikel Basterrechea, Hans Bisgaard, Leda Chatzi, Eva Corpeleijn and 48 more

Registry-linked trialOpen access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04689386 (Efecto De La Fisioterapia Respiratoria Sobre El Desarrollo De Niños/as Prematuros. Estudio Longitudinal.), which is not on this map. Cited by 141 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 10 pooled it
27.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04689386 nacompletednot on this mapstarted 2021, after this paper: background citation

Efecto De La Fisioterapia Respiratoria Sobre El Desarrollo De Niños/as Prematuros. Estudio Longitudinal.

TypeinterventionalSponsorUniversidad de MurciaRan2021 to 2024Enrolled51ConditionsDevelopment, Infant, Respiratory Distress Syndrome in Premature InfantArmsGroup I (GE-I) - Stimulation of "reflex rolling" from the Vojta method, Group II (GE-II) - expiratory flow increase technique
3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 10 syntheses or guidelines pooled it, 357 citations in OpenAlex.

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  11. Noninvasive Oscillometry to Measure Pulmonary Mechanics in Preterm Infants.American journal of respiratory and critical care medicine · 2021
    Trial
  12. Postnatal growth and childhood asthma in preterm and full-term twins: A cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
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81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

58 authors at 20 institutions in 16 countries.

Agnes M M Sonnenschein-van der VoortGeneration R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Paediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Lidia R ArendsDepartment of Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands; Institute of Pedagogical Sciences, Erasmus University Rotterdam, Rotterdam, The Netherlands; Institute of Psychology, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Johan C de JongsteDepartment of Paediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Isabella Annesi-MaesanoEPAR, UMR-S 707 INSERM Paris, Paris, France; EPAR, UMR-S 707, Université Pierre et Marie Curie Paris 06, Paris, France.
S Hasan ArshadDavid Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport, Isle of Wight, United Kingdom.
Henrique BarrosDepartment of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal.
Mikel BasterrecheaPublic Health Division of Gipuzkoa, Gipuzkoa, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain.
Hans BisgaardCopenhagen Prospective Studies on Asthma in Childhood (COPSAC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark.
Leda ChatziDepartment of Social Medicine, School of Medicine, University of Crete, Crete, Greece.
Eva CorpeleijnDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Sofia CorreiaDepartment of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal.
Leone C CraigApplied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Graham DevereuxApplied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Cristian DogaruInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Miroslav DostalInstitute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Karel DuchenDivision of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, and Pediatric Clinic, County Council of Östergötland County Council, Linköping, Sweden.
Merete EggesbøDepartment of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
C Kors van der EntDepartment of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Maria P FantiniDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Francesco ForastiereDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Urs FreyUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Ulrike GehringInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Davide GoriDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Anne C van der GugtenDepartment of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Wojciech HankeNofer Institute of Occupational Medicine, Department of Environmental Epidemiology, Lodz, Poland.
A John HendersonSchool of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Barbara HeudeINSERM, Center for Research in Epidemiology and Population Health, U1018, Lifelong Epidemiology Of Obesity, Diabetes, and Renal Disease Team, Villejuif, France; University Paris-Sud, Villejuif, France.
Carmen IñiguezSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain; Center for Public Health Research (CSISP), University of Valencia, Valencia, Spain; Faculty of nursery and chiropody, University of Valencia, Valencia, Spain.
Hazel M InskipMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.
Thomas KeilInstitute of Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany; Institute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
Cecily C KelleherSchool of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Ireland.
Manolis KogevinasNational School of Public Health, Athens, Greece.
Eskil Kreiner-MøllerCopenhagen Prospective Studies on Asthma in Childhood (COPSAC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark.
Claudia E KuehniInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Leanne K KüpersDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Kinga LanczDepartment of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia.
Pernille S LarsenSection of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Susanne LauDepartment of Paediatric Pneumology and Immunology, Charité University Medical Centre, Berlin, Germany.
Johnny LudvigssonDivision of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, and Pediatric Clinic, County Council of Östergötland County Council, Linköping, Sweden.
Monique MommersDepartment of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands.
Anne-Marie Nybo AndersenSection of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Lubica PalkovicovaDepartment of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia.
Katharine C PikeClinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Costanza PizziCancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.
Kinga PolanskaNofer Institute of Occupational Medicine, Department of Environmental Epidemiology, Lodz, Poland.
Daniela PortaDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Lorenzo RichiardiCancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.
Graham RobertsDavid Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport, Isle of Wight, United Kingdom.
Anne SchmidtDivision of Respiratory Medicine, Department of Pediatrics, Inselspital, University of Bern, Bern, Switzerland.
Radim J SramInstitute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Jordi SunyerSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain; Institut Municipal d'Investigació Mèdica (IMIM)-Hospital del Mar, Barcelona, Spain.
Carel ThijsDepartment of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands.
Maties TorrentIB-SALUT, Area de Salut de Menorca, Balearic Islands, Spain.
Karien ViljoenSchool of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Ireland.
Alet H WijgaCentre for Prevention and Health Services Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Martine VrijheidSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain.
Vincent W V JaddoeGeneration R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands.
Liesbeth DuijtsDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Paediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Paediatrics, Division of Neonatology, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: l.duijts@erasmusmc.nl.
Erasmus MC · NLUniversity of Copenhagen · DKCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESCzech Academy of Sciences, Institute of Experimental Medicine · CZInstitute of Social and Preventive Medicine · CHLinköping University · SEMaastricht University · NLNofer Institute of Occupational Medicine · PLSlovak Medical University · SKUniversidade do Porto · PTUniversity College Dublin · IEUniversity of Aberdeen · GBUniversity of Bologna · ITUniversity of Turin · ITCharité - Universitätsmedizin Berlin · DEDavid Hide Asthma and Allergy Research Centre · GBGentofte Hospital · DKInserm · FRInstituto de Investigación Biomédica de Salamanca · ESMRC Lifecourse Epidemiology Unit · GB

Funding

Early Childhood Development and PCB Exposures in Slovak*R01CA096525 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI HERTZ-PICCIOTTO, IRVA · 2001 to 2005
$2.3M
Arthritis Research UKBritish Heart FoundationMedical Research Council G0400473Medical Research Council G0800766Medical Research Council G0900453Medical Research Council MC_PC_15018Medical Research Council MC_UP_A620_1017NCI NIH HHS R01 CA096525Wellcome Trust 092731Wellcome Trust 102215
6 · The paper itself

Abstract

backgroundPreterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results.

objectivesWe performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years).

methodsFirst, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes.

resultsYounger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27).

conclusionYounger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.

Indexed as

AsthmaBirth WeightGestational AgePremature BirthWeight GainEuropeFemaleHumansInfantInfant, NewbornMaleRisk Factorsasthmachildrencohort studiesepidemiologyGestational ageinfant growthlow birth weightwheezing

Identifiers

PMID24529685
PMCPMC4024198
OpenAlexW1973250128

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.